120例BNP异常的手足口病患者病原学检测分析  

Detection and analysis of 120 cases of HFMD patients with abnormal BNP pathogen

作　　者：杨晓双[1] 姚晓玲[1] 席辰 郑岚[1] YANG Xiaoshuang;YAO Xiaoling;XI Chen;ZHENG Lan(Bengbu NO.3 Hospital,Bengbu 233000,China)

机构地区：[1]蚌埠市第三人民医院,安徽蚌埠233000

出　　处：《包头医学院学报》2018年第7期48-49,共2页Journal of Baotou Medical College

摘　　要：目的:分析2015至2016年蚌埠市手足口病伴脑钠肽(brainnatriureticpeptide,BNP)异常患儿的病原学特点,为制定诊疗措施及预后提供依据。方法:取患者咽拭子和肛拭子标本,用荧光PCR法检测肠道病毒通用型(EV)、柯萨奇病毒A16型(Cox Al6)、肠道病毒71型(EV71)。结果:在120例临床检测BNP异常的手足口病患者中,肠道病毒核酸阳性110例,阳性率91.67%,其中EV71感染84例,发生率为70.0%;Cox Al6感染17例,发生率为14.17%;其他型肠道病毒感染9例,发生率为7.5%。结论:引起手足口病患儿BNP异常改变的病原体主要为EV71病毒;当病原学检测结果提示EV71感染时,应警惕BNP异常改变并密切监测。Objective:To analyze the etiological characteristics of children with hand-foot-mouth disease(HFMD)with abnormal brain natriuretic peptide(BNP)in Bengbu from 2015 to 2016,and provide the basis for the formulation of treatment measures and prognosis.Method:Samples of throat swabs and anus swabs from patients were taken to make detection of enterovirus general type(EV),coxsackievirus A16(CoxAl6),enterovirus 71(EV71)by fluorescence PCR.Results:In 120 patients of HFMD with BNP,there were 109 cases of positive enterovirus nucleic acid,with the positive rate at 91.67%,in which there were 84 cases of EV71 infection(70%),7 cases of CoxAl6 infection(5.83%)and 18 cases of other type of enterovirus infection(15.0%).Conclusion:The main cause of abnormal changes of BNP in children with HFMD is EV71 virus.When the results of pathogeny detection suggest EV71 infection,abnormal changes should be alerted and close monitoring of BNP should be made.

关 键 词：手足口病 病因学 肠道病毒71型 脑钠肽 

分 类 号：R725.1[医药卫生—儿科]