细辛及其制剂致8例不良反应/事件分析  

作　　者：樊萍[1] 高洋洋[1] 郭毅 杨梅梅[1] 徐珽[1] 

机构地区：[1]四川大学华西医院临床药学部,四川成都610041

出　　处：《中国药业》2017年第A02期225-226,共2页China Pharmaceuticals

摘　　要：目的探讨细辛及其制剂药物不良反应/事件(ADR/ADE)发生的类型和特点,为临床安全合理用药提供参考。方法检索中国期刊全文数据库(CNKI)、维普、万方等数据库,共检索1950年至2015年3月发表的有关细辛的不良反应/事件的文献。结果剔除综述文献、重复病例报告等,共8篇病例报告文献进行分类、统计和分析。ADR/ADE多发生于30~50岁,发病时间主要集中在服药后2h内,不良反应类型主要为心功能损害,其次是神经系统、呼吸系统、消化系统、循环系统等损害。结论临床应用细辛宜从小剂量开始,逐渐加量,大剂量使用时需适当延长煎煮时间,定期监测不良反应,避免严重不良反应的发生。Objective To nvestigate the causes and characteristics of the adverse drug reaction/event(ADR/ADE)cases induced by Asarum siebeldii and its preparation,provide references for clinical rational drug use.Methods ADR/ADE of asarum was collected and analyzed by retrieving a case report in CNKI,VIP and Wanfang from 1950 to March 2015.Results To eliminate the review and repeat literature,a total of 8 ADR/ADE cases reported in the literature for classification,statistics and analysis.The patients aged 30-50 years old had higher probability of ADR/ADE occurrence.ADRs often happened within 2 h after medication and involved cardiac function damage,nervous system damage,respiratory system damage,digestive system damage and circulatory system damage.Conclusion Clinical application of Asarum siebeldii should be started with minimal effective dosage and then to increase the dose gradually with caution,extend the decocting time with large dose.ADR monitoring should be strengthened to improve the rational use of drug.

关 键 词：细辛 制剂 药品不良反应 药品不良事件 

分 类 号：R288[医药卫生—中药学]