回生口服液联合盐酸羟考酮缓释片治疗中重度癌痛70例疗效观察  

作　　者：敬新蓉[1] 李青 李莉[1] 江恒 孙薏[1] 

机构地区：[1]中国人民解放军第452医院肿瘤科,四川成都610061

出　　处：《中国药业》2017年第A01期41-42,共2页China Pharmaceuticals

摘　　要：目的观察回生口服液联合盐酸羟考酮缓释片治疗中重度癌痛患者的临床疗效。方法将140例中重度癌痛患者随机均分成两组,对照组给予盐酸羟考酮缓释片规范癌痛治疗,观察组在此基础上联合回生口服液联合治疗。结果用药后24,72h观察组癌痛缓解率均高于对照组,但差异无统计学意义(P>0.05);用药后72h达到NRS<3分,所用盐酸羟考酮缓释片平均剂量及疗程结束盐酸羟考酮缓释片用量调整,观察组较对照组减少(P<0.05)。观察组便秘、恶心、呕吐发生率明显低于对照组(P<0.05)。结论盐酸羟考酮缓释片联合回生口服液规范癌痛治疗可提高癌痛止痛疗效,减轻不良反应。Objective To observe the Huisheng oral liquid combined with Oxycodone Hydrochloride Prolonged-Release Tablets in the treatment of cancer patients with moderate to severe cancer pain.Methods The 140 patients with moderate to severe cancer pain were randomly divided into 2 groups according to the order of diagnosis and treatment.The control group was given standard treatment of cancer pain with Oxycodone Hydrochloride Prolonged-Release Tablets,the observation group was given Huisheng oral liquid on the basis of standard treatment.Results After the treatment of 24,72 h,the cancer pain remission rate of observation group was higher than that of control group,but the difference was not statistically significant(P>0.05).To the average dose of Oxycodone Hydrochloride Prolonged-Release Tablets to NRS score was less than 3 after the administration of 72 h,and the adjustment dose of Oxycodone Hydrochloride Prolonged-Release Tablets after the end of the treatment,the observation group showed significant decrease compared with the control group(P<0.05).The incidence of constipation,nausea and vomiting in the observation group was significantly lower than that in the control group(P<0.05).Conclusion Oxycodone Hydrochloride Prolonged-release Tablets combined with Huisheng oral liquid for treating cancer pain can improve the curative effect,and reduce the adverse reaction.

关 键 词：癌痛 回生口服液 盐酸羟考酮缓释片 中西医结合 药品不良反应 

分 类 号：R2-031[医药卫生—中西医结合]