冠心病介入术后缬沙坦对冠脉再狭窄的影响  

Effect of Valsartan on coronary restenosis after coronary intervention

作　　者：刘颖芝[1] 熊振宇 熊龙根[3] LIU Yingzhi;XIONG Zhenyu;XIONG Longgen(Department of Clinical Medicine,Guangzhou Medical University,Guangdong Province,Guangzhou 510000,China;Department of Cardiology,the Second People′s Hospital of Guangdong Province,Guangdong Province,Guangzhou 510000,China;Department of Cardiology,the Second Affiliated Hospital of Guangzhou Medical University,Guangdong Province,Guangzhou 510000,China)

机构地区：[1]广州医科大学临床医学系,广东广州510000 [2]广东省第二人民医院心内科,广东广州510000 [3]广州医科大学第二附属医院心内科,广东广州510000

出　　处：《中国医药导报》2018年第22期81-84,共4页China Medical Herald

基　　金：广东省科技计划项目(20130319c)

摘　　要：目的探讨冠心病介入术后缬沙坦对冠脉再狭窄的影响。方法选择2016年1月~2017年11月在广州医科大学第二附属医院行冠脉介入术+放支架的患者98例,按照随机抽取病例号原则随机分为实验组(n=49)和对照组(n=49)。对照组给予常规治疗,实验组在常规基础上加入缬沙坦胶囊治疗,同时选择30例行冠脉造影但未放支架的作为阴性对照组。分析三组患者超声心动图心室射血分数(EF)值、不良心血管事件、冠脉再狭窄的发生情况和内皮素-1(ET-1)、超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)、脂蛋白相关磷脂酶A2(LP-PLA2)的含量变化。结果实验组有5例发生冠脉再狭窄,发生率为10.20%,对照组有13例发生冠脉再狭窄,发生率为26.53%,两组比较差异有统计学意义(P<0.05)。术后4周,三组患者的ET-1、hs-CRP、IL-6、LP-PLA2、EF值与同组术前比较,差异有统计学意义(P<0.05)。术后4周,实验组ET-1、hs-CRP、IL-6、LP-PLA2与对照组、阴性对照组比较,差异有统计学意义(P<0.05),而对照组与阴性对照组比较,差异无统计学意义(P>0.05)。术后4周,实验组与对照组、阴性对照组EF值比较,差异均有统计学意义(P<0.05)。实验组的不良心血管事件发生情况较对照组少,差异有统计学意义(P<0.05)。结论冠心病介入术后经缬沙坦治疗后可有效降低冠脉再狭窄的发生,降低内皮素及炎症因子的含量,明显减少不良心血管事件发生,改善超声心动图EF值。Objective To investigate the effect of Valsartan on coronary restenosis after coronary intervention.Methods A total of 98 patients who underwent coronary intervention and stent placement at the Second Affiliated Hospital of Guangzhou Medical University from January 2016 to November 2017 were randomly divided into experimental group(n=49)and control group(n=49)according to the principle of randomly selected case numbers.The control group received routine treatment.The experimental group were treated with Valsartan Capsules on the basis of routine treatment.At the same time,30 patients who underwent coronary angiography without stenting were selected as negative control group.The echocardiographic EF values,the occurrence of adverse cardiovascular events and coronary restenosis,and the contents of endothelin-1(ET-1),high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),lipoprotein-related phospholipids and enzyme A2(LP-PLA2)were analyzed in the three groups of patients.Results In the experimental group,there were 5 cases with coronary restenosis,with an incidence of 10.20%.In the control group,coronary restenosis occurred in 13 cases with an incidence of 26.53%,and the difference between the two groups was statistically significant(P<0.05).The ET-1,hs-CRP,IL-6,LP-PLA2 and EF values of the three groups 4 weeks after surgery were compared with those before surgery,and the differences were statistically significant(P<0.05).Four weeks after surgery,the differences of ET-1,hs-CRP,IL-6,LP-PLA2 and EF values in the experimental group,the control group and the negative control group were statistically significant(P<0.05).Four weeks after surgery,experimental ET-1,the hs-CRP,IL-6,LP-PLA2 were compared with control group,negative control group,and the differences were statistically significant(P<0.05),while the control group compared with negative control group,there was no statistically significant difference(P>0.05).Echocardiographic EF values of the experimental group,the control group and the negative control g

关 键 词：冠心病介入术 缬沙坦 冠脉再狭窄 

分 类 号：R541.4[医药卫生—心血管疾病]