基于T_(>MIC)计算模型评价亚胺培南的临床方案及疗效  

Evaluation on Clinical Program and Therapeutic Efficacy of Imipenem Based on T_(>MIC) Calculation Model

作　　者：张丹[1] 陈文倩[1] 王晓雪[1] 辛文妤[2] 崔刚[1] 张相林[1] ZHANG Dan;CHEN Wenqian;WANG Xiaoxue;XIN Wenshu;CUI Gang;ZHANG Xianglin(Dept.of Pharmacy,China-Japan Friendship Hospital,Beijing 100029,China;School of Pharmacy,Binzhou Medical College,Shandong Yantai 264003,China)

机构地区：[1]中日友好医院药学部,北京100029 [2]滨州医学院药学院,山东烟台264003

出　　处：《中国药房》2018年第15期2105-2108,共4页China Pharmacy

基　　金：国家自然科学基金青年科学基金项目(No.81503339)

摘　　要：目的:利用T_(>MIC)计算模型评价不同T_(>MIC)下亚胺培南的临床方案及疗效。方法:采用回顾性方法,选取2015年10月-2017年6月在中日友好医院住院期间行亚胺培南血药浓度检测的患者107例,记录其基本信息和用药情况,运用SPSS 19.0软件按T_(>MIC)计算模型计算不同给药方案下不同患者亚胺培南的T_(>MIC),依据不同T_(>MIC)分为≤40%组、>40%~70%组、>70%~100%组和>100%组,比较各组患者的亚胺培南用药持续时间、降钙素原(PCT)降低百分比。结果:纳入研究患者97例,其中≤40%组18例、>40%~70%组35例、>70%~100%组34例、>100%组10例。4组患者基线水平差异无统计学意义(P>0.05),其亚胺培南用药持续时间分别为(10.7±2.69)、(8.71±3.48)、(8.50±4.21)、(9.00±4.87)d,PCT降低百分比分别为(37.00±28.83)%、(53.43±21.66)%、(58.67±16.53)%、(47.25±24.71)%。结论:临床使用亚胺培南进行抗感染治疗时调整治疗方案使其T_(>MIC)在>70%~100%范围内能获得较好的抗菌效果。OBJECTIVE:To evaluate clinical program and therapeutic efficacy of imipenem by using T>MIC calculation model under different T>MIC.METHODS:By retrospective method,107 patients underwent blood concentration monitoring of imipenem were collected from China-Japan Friend Hospital during Oct.2015-Jun.2017.General information and drug use were recorded.T>MIC of imipenem in different patients receiving different programs was calculated according to T>MIC calculation model by using SPSS 19.0 software.According to different T>MIC,those patients were divided into≤40%group,>40%-70%group,>70%-100%group and>100%group.Medication duration of imipenem use and the percentage of PCT decrease were compared among those groups.RESULTS:Totally 97 patients were included in the study.There were 18 cases in≤40%group,35 cases in>40%-70%group,34 cases in>70%-100%group and 10 cases in>100%group.There was no statistical significance in baseline level of the body among 4 groups(P>0.05).The medication duration of imipenem use were(10.7±2.69),(8.71±3.48),(8.50±4.21)and(9.00±4.87)d,respectively.The percentage of PCT decrease were(37.00±28.83)%,(53.43±21.66)%,(58.67±16.53)%and(47.25±24.71)%,respectively.CONCLUSIONS:When imipenem is used for anti-infection treatment,that therapy program is adjusted to maintain T>MIC between>70%-100%may achieve good antibacterial efficacy.

关 键 词：亚胺培南 T>MIC 抗菌疗效 用药持续时间 PCT降低百分比 

分 类 号：R969[医药卫生—药理学] R969.3[医药卫生—药学]