基于国内外指南评价某院含抗高血压药物的处方联用的合理性  

Evaluation of Prescription of Combined Use of Antihypertensive Drugs in a Hospital Based on the Domestic and Foreign Guidelines

作　　者：袁进[1] 刘贺萍[1] 许百虹[2] 梁虹艺[1] 杨晨[1] 李健[1] 董俪雯 曾颖[2] YUAN Jin;LIU Heping;XU Baihong;LIANG Hongyi;YANG Chen;LI Jian;DONG Liwen;ZENG Ying(Dept.of Pharmacy,Guangzhou General Hospital of Guangzhou Military Command,Guangzhou 510010,China;Dept.of Pharmacy,Guangdong Provincial People’s Hospital,Guangzhou 510080,China;College of Pharmacy,Guangdong Pharmaceutical University,Guangzhou 510006,China)

机构地区：[1]广州军区广州总医院药学部,广州510010 [2]广东省人民医院药学部,广州510080 [3]广东药科大学药学院,广州510006

出　　处：《中国药房》2018年第15期2114-2118,共5页China Pharmacy

基　　金：广州市科技创新平台开放共享专项项目(No.151800031);广州市科技计划项目(No.201709010006)

摘　　要：目的:为临床合理使用抗高血压药物提供参考。方法:利用处方点评系统,随机抽取2016年1-12月广东省人民医院心血管内科门诊处方中含抗高血压药物的处方进行回顾性研究,统计患者的性别、年龄、诊断结果、使用的抗高血压药物名称及其药理学分类等,将抗高血压药物联用情况与国内、外高血压防治指南中推荐的方案进行比较,评价其合理性。结果与结论:共收集含抗高血压药物的处方4 308份,其中联用处方2 183份,占纳入处方的50.67%。联用处方中,以二联为主,有1 420份,占联用处方的65.05%;以含血管紧张素Ⅱ受体阻滞药的处方最多,占联合用药处方的74.94%;符合指南推荐方案的联用处方有1 627份,占联合用药处方的74.53%;不合理联用处方有420份,占联用处方的19.24%。其中指南未推荐的联用处方,因为缺乏详细的患者病历资料,其有效性和安全性有待进一步验证。OBJECTIVE:To provide reference for rational use of antihypertensive drugs in clinic.METHODS:In retrospective study,antihypertensive drug prescriptions were randomly selected from cardiovascular medicine department of Guangdong Provincial People’s Hospital during Jan.-Dec.2016,by using prescription comment system.The patient’s gender,age,diagnosis,name and pharmacological classification of antihypertensive drugs were counted.Combined use of antihypertensive drugs was compared with the plan recommended by domestic and foreign hypertensive prevention and treatment guidelines.The rationality of antihypertensive drug use was evaluated.RESLUTS&CONCLUSIONS:Totally 4 308 prescriptions of antihypertensive drugs were collected,among which there were 2 183 prescriptions of drug combination,accounting for 50.67%of total.Among drug combination,there were 1 420 prescriptions of two-drug combination,accounting for 65.05%of drug combination prescriptions;the most prescriptions contained ARB,accounting for 74.94%of drug combination prescriptions;1 627 prescriptions of drug combination were agree with plans recommended by guidelines,accounting for 74.53%of drug combination prescriptions;there were 420 prescriptions of irrational drug combination,accounting for 19.24%of drug combination prescriptions.The effectiveness and safety of the prescriptions of drug combination which were not recommended by guidelines need to be further verified due to absence of detailed medical records.

关 键 词：处方 抗高血压药物 联合用药 指南 

分 类 号：R969.3[医药卫生—药理学] R972.4[医药卫生—药学]