法舒地尔辅助治疗慢性心力衰竭患者临床效果的Meta分析  

Meta-analysis of the clinical effects of fasudil in the treatment of patients with chronic heart failure

作　　者：李春雷[1] 李竹琴[1] Li Chunlei;Li Zhuqin(CCU Department of Cardiology,The First Affiliated Hospital of Harbin Medical University,Harbin,150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院心内科,哈尔滨150001

出　　处：《中国循证心血管医学杂志》2018年第7期800-804,共5页Chinese Journal of Evidence-Based Cardiovascular Medicine

基　　金：哈尔滨市科技局科技创新人才项目基金(2013RFXYJ088)

摘　　要：目的运用Meta分析方法评价法舒地尔辅助治疗慢性心力衰竭患者的临床效果。方法计算机检索中国期刊全文数据库(CNKI)、中文科技期刊全文数据库(VIP)、万方数字化期刊全文库、Pubmed和Cochrane library,对纳入的随机对照试验文献进行质量评价,并采用Rev Man 5.2软件进行Meta分析。结果共纳入15篇随机对照试验,共1353例患者。Meta分析结果显示,与常规治疗组相比,法舒地尔加用常规治疗可有效提高慢性心力衰竭患者的临床疗效(RR=1.16,95%CI:1.10~1.23,P<0.01),延长6分钟步行试验距离(WMD=49.02,95%CI:42.85~55.2,P<0.01),提升左室射血分数(WMD=0.06,95%CI:0.05~0.07,P<0.01),以及缩小左室舒张末期内径(WMD=-3.01,95%CI:-4.18^-1.84,P<0.01)和左心室收缩末期内径(WMD=-3.74,95%CI:-4.88^-2.60,P<0.01)。结论法舒地尔辅助治疗慢性心力衰竭患者可改善心功能,并能抑制左室重塑,提高临床疗效,但仍需开展高质量的药物临床试验。Objective Using meta-analysis to evaluate the clinical effect of fasudil therapy in patients with chronic heart failure.Methods We searched articles in China Journal Full-text Database(CNKI),Chinese PSTP(VIP),Wanfang database,Pubmed and Cochrane library.The included randomized controlled trial literature was quality assessed and meta-analyzed using RevMan 5.2 software.Results A total of 15 randomized controlled trials involving a total of 1353 patients were included.The results of Meta-analysis showed that,compared with the conventional treatment group,fasudil plus routine treatment can effectively improve the clinical efficacy of patients with chronic heart failure[RR=1.16,95%CI:1.10~1.23,P<0.01],prolonged 6-minute walk distance[WMD=49.02,95%CI:42.85~55.2,P<0.01],improve left ventricular ejection fraction[WMD=0.06,95%CI:0.05~0.07,P<0.01],reduce left ventricular end-diastolic diameter[WMD=-3.01,95%CI:-4.18^-1.84,P<0.01]and left ventricular end-systolic diameter[WMD=-3.74,95%CI:-4.88^-2.60,P<0.01].Conclusion Fasudil therapy can improve the cardiac function in patients with chronic heart failure,and can inhibit left ventricular remodeling,improve clinical efficacy,but still need to carry out high quality drug clinical trials.

关 键 词：法舒地尔 慢性心力衰竭 临床效果 META分析 

分 类 号：R541.61[医药卫生—心血管疾病]