呼出气一氧化氮和过敏原检测在1～6岁儿童喘息性疾病中的应用价值  

Application Value of Detection of Fe NO and Allergen in 1 to 6 Years Old Children with Asthmatic Diseases

作　　者：吴丙美 杨雪冰[1] 杨振朋[1] 翟健[2] WU Bingmei;YANG Xue-bing;YANG Zhen-peng;ZHAI Jian(Department of Pediatrics,the People's Hospital of Tangshan,Tangshan 063001,China;Department of Head and Neck Surgery,the People's Hospital of Tangshan,Tangshan 063001,China)

机构地区：[1]河北省唐山市人民医院儿科,063001 [2]河北省唐山市人民医院头颈外科,063001

出　　处：《实用心脑肺血管病杂志》2018年第6期79-82,共4页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：河北省卫生和计划生育委员会计划项目(20181227)

摘　　要：目的探讨呼出气一氧化氮(FeNO)和过敏原检测在1～6岁儿童喘息性疾病中的应用价值。方法选取2017年1月—2018年1月唐山市人民医院收治的1～6岁呼吸道疾病患儿257例,根据有无喘息症状分为喘息组163例和非喘息组94例。两组患儿均进行FeNO浓度检测和过敏原检测,比较两组患儿治疗前FeNO浓度和过敏原检测结果;并比较喘息组患儿治疗前后FeNO浓度,血清总免疫球蛋白E(tIgE)水平及尘螨、蛋清、牛奶特异性免疫球蛋白E(sIgE)水平。结果治疗前喘息组患儿FeNO浓度,食入性过敏原及吸入性过敏原阳性率,血清tIgE水平及尘螨、蛋清、牛奶sIgE水平高于非喘息组(P<0.05)。治疗后喘息组患儿FeNO浓度,血清tIgE水平及尘螨、蛋清、牛奶sIgE水平低于治疗前(P<0.05)。Pearson相关分析结果显示,FeNO浓度与1～6岁喘息性疾病患儿血清tIgE水平(r=0.514)及尘螨(r=0.429)、蛋清(r=0.824)、牛奶(r=0.415)sIgE水平呈正相关(P<0.05)。结论 FeNO和过敏原检测有助于提高1～6岁儿童喘息性疾病的管理和评估水平。Objective To investigate the application value of detection of FeNO and allergen in 1 to 6 years old children with asthmatic diseases.Methods A total of 257 children(1 to 6 years old)with respiratory tract diseases were selected in the People's Hospital of Tangshan from January 2017 and January 2018,and they were divided into A group(with asthmatic diseases,n=163)and B group(without asthmatic diseases,n=94).Children in the two groups received detection of FeNO and allergen,FeNO concentration and allergen detection results before treatment were compared between the two groups;FeNO concentration,serum levels of tIgE,sIgE of dust mite,egg white and milk before and after treatment were compared in A group.Results Before treatment,FeNO concentration,positive rates of ingestive and inhalational allergens,serum levels of tIgE,sIgE of dust mite,egg white and milk in A group were statistically significantly higher than those in B group(P<0.05).After treatment,FeNO concentration,serum levels of tIgE,sIgE of dust mite,egg white and milk in A group were statistically significantly lower than those before treatment(P<0.05).Pearson correlation analysis results showed that,FeNO concentration was positively correlated with serum levels of tIgE(r=0.514),sIgE of dust mite(r=0.429),egg white(r=0.824)and milk(r=0.415),respectively(P<0.05).Conclusion Detection of FeNO and allergen is helpful to improve the management and evaluation level for 1 to 6 years old children with asthmatic diseases.

关 键 词：呼吸道疾病 儿童 喘息性疾病 呼出气一氧化氮 过敏原 

分 类 号：R725.6[医药卫生—儿科]