心脏外科术后急性肺损伤主要生物标志物的研究进展  

Research Progress on Major Biomarkers of Acute Lung Injury after Cardiac Surgical Procedures

作　　者：张航[1] 虞敏[1] 谷彤彤 袁忠祥[1] ZHANG Hang;YU Min;GU Tong-tong;YUAN Zhong-xiang(Department of Cardiac and Macrovascular Surgery,the First People's Hospital Affiliated to Nanjing Medical University,Shanghai 200080,China;Central Laboratory,the First People's Hospital of Nanjing Affiliated to Nanjing Medical University,Nanjing 210006,China)

机构地区：[1]南京医科大学附属上海市第一人民医院心脏及大血管外科,上海市200080 [2]南京医科大学附属南京市第一医院中心实验室,江苏省南京市210006

出　　处：《实用心脑肺血管病杂志》2018年第6期108-112,共5页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：国家自然科学基金青年科学基因项目(81300094)

摘　　要：急性肺损伤(ALI)是一种急性肺部炎性损伤性疾病,是心脏外科术后常见并发症之一,以肺泡上皮细胞及毛细血管内皮细胞损伤为主要病理特征,主要临床表现为急性低氧性呼吸功能不全。ALI可进展为急性呼吸窘迫综合征(ARDS),病死率为27%～45%,严重威胁患者生命安全及生存质量。近年来,大量研究发现ALI患者血清及支气管肺泡灌洗液(BALF)中存在多种生物标志物。本文通过检索国内外相关文献,综述了心脏外科术后ALI主要生物标志的研究进展,以期为ALI的早期诊断提供参考。Acute lung injury(ALI),as one kind of acute pulmonary inflammatory injury diseases,is one of the common complications after cardiac surgical procedures,which mainly performed as injury of alveolar epithelial cells and capillary endothelial cells in pathology,performed as acute hypoxic respiratory insufficiency on clinic.ALI may develop into acute respiratory distress syndrome with fatality rate from 27%to 45%,which was seriously threatening the patients'life safety and quality of life.In recent years,a lot of researches found multiple biomarkers of ALI in serum and BALF.This paper searched literatures published in home and abroad,reviewed the research progress on major biomarkers of ALI after cardiac surgical procedures,to provide a reference for the early diagnosis of ALI.

关 键 词：急性肺损伤 心脏外科手术 生物标志物 综述 

分 类 号：R563[医药卫生—呼吸系统]