NCPAP序贯高流量鼻导管湿化氧疗联合猪肺磷脂注射液治疗新生儿呼吸窘迫综合征的疗效观察  

Curative Effect of Sequential NCPAP and Humidified High Flow Nasal Cannula Combined with Poractant Alfa Injection in the Treatment of Neonatal Respiratory Distress Syndrome

作　　者：张静[1] ZHANG Jing(Neonatal Health Division,Anyang Maternal and Child Health Care Hospital,Anyang Henan 455000,China)

机构地区：[1]安阳市妇幼保健院新生儿保健科,河南安阳455000

出　　处：《药品评价》2018年第15期55-57,64,共4页Drug Evaluation

摘　　要：目的:探究鼻塞持续气道正压通气(NCPAP)序贯高流量鼻导管湿化氧疗(HHFNC)联合猪肺磷脂注射液治疗新生儿呼吸窘迫综合征(NRDS)的治疗效果。方法:选取安阳市妇幼保健院NRDS患儿114例.按随机数字表法分为实验组(n=57)与对照组(n=57)。对照组采取NCPAP序贯HHFNC治疗.实验组采取NCPAP序贯HHFNC联合猪肺磷脂注射液治疗,统计两组治疗24h后治疗效果、治疗前与治疗24h后血气分析有关指标[血酸碱度(PH)、血二氧化碳分压(PaCO_2)、血氧分压(PaO_2)]水平、住院时间、住院费用。结果:实验组总有效率92.98%高于对照组75.44%(P<0.05):治疗前两组PH、PaCO_2、PaO_2水平对比,无显著差异(P>0.05),治疗24h后实验组PH、PaO_2水平高于对照组,PaCO_2水平低于对照组,差异有统计学意义(P<0.05);与对照组相比,实验组住院时间较短,住院费用较低,差异有统计学意义(P<0.05)。结论:应用NCPAP序贯高流量鼻导管湿化氧疗联合猪肺磷脂注射液治疗新生儿呼吸窘迫综合征能显著提高治疗效果,改善患儿血气情况,促进患儿恢复。Objective:To investigate the treatment effect of sequential nasal continuous positive airway pressure(NCPAP)and humidified high flow nasal cannula(HHFNC)combined with Poractant Alfa injection in the treatment of neonatal respiratory distress syndrome(NRDS).Methods:A total of 114 cases of children with NRDS in our hospital were randomly divided into experimental group(n=57)and control group(n=57).The control group was treated with sequential NCPAP and HHFNC,and the experimental group was treated with sequential NCPAP and HHFNC combined with Poractant Alfa injection.The treatment effect after 24 h of treatment,the blood gas analysis index before and after 24 h of treatment[blood acidity and alkalinity(PH),partial pressure of the carbon dioxide(PaCO2)and partial pressure of the oxygen(PaO2)],the hospitalization time and the cost of hospitalization of two groups were statistically measured.Results:The total effective rate of the experimental group was 92.98%,higher than that of the control group(75.44%),and the difference was statistically significant(P<0.05).There was insignificant difference in the levels of PH,PaCO2 and PaO2 between the two groups before treatment(P>0.05).After treatment for 24 h,the levels of PH and PaO2 in the experimental group were higher than those in the control group,while the PaCO2 level was lower in the experimental group than in the control group,and the difference was statistically significant(P<0.05).Compared with the control group,the experimental group had shorter hospitalization time and lower hospitalization expenses(P<0.05).Conclusion:Sequential NCPAP and humidified high flow nasal cannula combined with Poractant Alfa injection in treatment of neonatal respiratory distress syndrome can significantly improve the therapeutic effect,improve the blood gas and promote the recovery of children.

关 键 词：新生儿呼吸窘迫综合征 NCPAP 高流量鼻导管湿化氧疗 猪肺磷脂注射液 

分 类 号：R985[医药卫生—药品]