长链非编码RNA--抗病毒天然免疫应答的新兴调控因子  

Long non-coding RNAs: Emerging regulators of antiviral innate immune responses

作　　者：张华伟 孟星宇[1] 李连峰[1] 杨玉莹[2] 仇华吉[1] Huawei Zhang;Xingyu Meng;Lianfeng Li;Yuying Yang;Huaji Qiu(State Key Laboratory of Veterinary Biotechnology,Harbin Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Harbin 150069,China;College of Animal Sciences,Yangtze University,Jingzhou 434023,China)

机构地区：[1]中国农业科学院哈尔滨兽医研究所,兽医生物技术国家重点实验室,哈尔滨150069 [2]长江大学动物科学学院,荆州434023

出　　处：《遗传》2018年第7期525-533,共9页Hereditas（Beijing)

基　　金：国家自然科学基金项目(编号:31700139)资助

摘　　要：长链非编码RNA(long non-coding RNAs,lncRNAs)是长度超过200nt的非编码RNA分子的总称。作为一类重要的基因调控因子,lncRNAs在表观遗传学、转录及转录后等多个水平调控靶基因的表达。近年来的研究表明,许多lncRNAs可被病毒或干扰素(interferon,IFN)诱导表达,并作为调控因子在IFN介导的抗病毒天然免疫应答中调节抗病毒相关基因的表达。本文重点阐述了lncRNAs在IFN介导的抗病毒天然免疫应答中的调控作用,尤其是对干扰素刺激基因(interferon-stimulated genes,ISGs)转录的调控作用,并归纳了lncRNAs、IFN和ISGs形成的调控网络,以期为从事lncRNAs调控IFN介导的抗病毒天然免疫应答机制研究的相关科研人员提供参考。Long non-coding RNAs(lncRNAs)are designated as the transcripts longer than 200 nucleotides without protein-coding capacity.As a category of important gene regulatory factors,lncRNAs regulate the expression of target genes at epigenetic,transcription and post-transcriptional levels by various mechanisms,such as chromatin remodeling,DNA modification,transcription inhibition and RNA-RNA interactions,etc.In recent years,studies have shown that many lncRNAs can be induced by viruses or interferon(IFN)and to regulate the expression of related antiviral genes in IFN-mediated antiviral innate immune responses.In this review,we focus on the regulation of lncRNAs in IFN-mediated antiviral innate immune responses,especially in the transcription of IFN-stimulated genes(ISGs).In addition,we summarize the regulatory network of lncRNAs,IFN and ISGs.This review will provide a valuable reference for the researchers working in this field.

关 键 词：长链非编码RNA 干扰素 干扰素刺激基因 抗病毒天然免疫应答 

分 类 号：Q756[生物学—分子生物学]