基于直线电机连续-步进运动的快速光声显微成像系统  

A Fast Photoacoustic Microscope Imaging System Based on Linear Motor Continuous-Stepping Motion

作　　者：程中文 杨思华 CHENG Zhongwen;YANG Sihua(MOE Key Laboratory of Laser Life Science&Institute of Laser Life Science,College of Biophotonics, South China Normal University,Guangzhou 510631,Guangdong,China)

机构地区：[1]华南师范大学,生物光子学研究院激光生命科学研究院,暨激光生命科学教育部重点实验室,广东广州510631

出　　处：《激光生物学报》2017年第5期414-418,共5页Acta Laser Biology Sinica

基　　金：国家自然科学基金(61627827,81630046,91539127,61331001,11774101);广东省科技计划项目(2015B020233016,2014B020215003,2014A020215031,2013B090500122)

摘　　要：报道了一种利用直线电机连续-步进的扫描方式进行光声显微成像的系统,该系统在运动时走弓字型路线,其中直线电机在X轴方向上连续运动,在Y轴方向上以步进的方式运动,采集卡只在X轴电机运动的过程中连续采集。该成像系统较之前振镜扫描的方式扫描的范围更大,可达到厘米尺度范围内的生物组织光声成像;较之前的步进电机逐点扫描的方式扫描速度明显提高。同时本文采用电机带动光和超声换能器一同扫描的方式,较光和超声换能器不动电机带动样品扫描的方式更灵活。另外利用包埋碳丝的模拟样品和在体小鼠耳朵血管来验证系统的成像能力。实验结果表明,这种快速光声显微成像方法及其系统可以实现在体组织的高分辨率成像,有望成为一种无创、实时的光声显微镜应用于生物医学当中。A system for two-dimensional photoacoustic imaging with a continuous-stepping scan of a linear motor is reported.The system is in the form of a bow-type curve during motion,in which the linear motor moves continuously in the X-axis direction,Y-axis direction to have a step by step movement,capture card in the X-axis motor movement in the process of continuous acquisition.The imaging system is larger than the previous method of scanning the galvanometer,and can reach the biological tissue photoacoustic imaging in the centimeter scale range.Compared with the previous stepping motor,the scanning speed can be improved obviously.At the same time,Driving the light and ultrasonic transducers without moving the motor can make the sample scanning more flexible.In addition,the use of embedded carbon wire simulation samples and in vivo mouse ear blood vessels to verify the imaging capabilities of the system.The experimental results show that this fast photoelectrical two-dimensional microscopic imaging system can be used to achieve high-resolution imaging in vivo,and is expected to be a noninvasive,real-time photoacoustic microscope for biomedicine.

关 键 词：连续-步进运动 快速光声成像 光声显微镜 

分 类 号：Q631[生物学—生物物理学]