紫杉醇结构类似物的分离分析研究  

The separation and analysis research of taxol analogues

作　　者：柴光盛 黄家明 张天玉 解粉莲 月琳 CHAI Guang-sheng;HUANG Jia-ming;ZHANG Tian-yu;XIE Fen-lian;YUE Lin(Qujing City of Quality and Technology Supervision of Comprehensive Detection Center,Qujing 655000,China;Yunnan Province Meat Products Quality Supervision and Inspection Center,Qujing 655000,China)

机构地区：[1]云南省曲靖市质量技术监督综合检测中心,云南曲靖655000 [2]云南省肉制品质量监督检验中心,云南曲靖655000

出　　处：《化学研究与应用》2018年第8期1343-1347,共5页Chemical Research and Application

基　　金：曲靖市质量技术监督综合检测中心自筹资金科研项目资助

摘　　要：本实验以分离以分离紫杉醇及其结构类似物为目标,采用分子印迹技术制备出具有优异分离性能的分子模板聚合物。通过平衡吸附实验系统为技术手段研究了功能单体种类,功能单体用量,交联剂用量,聚合条件对印迹分子的吸附性能的影响。采用不同手段表征了合成模板聚合物的性能。探讨了模板聚合物的识别机理及其作为固相萃取剂的应用前景。本研究建立了一种紫杉醇及其结构类似物的分离分析方法。In this study,a molecular template polymer with excellent properties to separating taxol and taxol analogus was prepared by using molecular inprinting.The effects of monomer species,dosage of functional monomer,the amount of crosslinking agent and polymerization conditions were systematically investigated by utilizing balanced adsorption experiment system.The properties of molecular template were characterized by using different characterization methods.The recognition mechanism of molecular template polymer and its application prospect were discussed.This study established a novel method to separate taxol and taxol analogues.

关 键 词：分子印迹技术 功能单体 交联剂 2-vp 10-dep 

分 类 号：O658[理学—分析化学]