聚己内酯药物控释材料的研究进展  

Research progress of PCL based materials for drug controlled release

作　　者：鲁手涛 徐海荣 刘黎明 曹文瑞 张海军 Lu Shoutao;Xu Hairong;Liu Liming;Cao Wenrui;Zhang Haijun(National United Engineering Laboratory for Biomedical Material Modification,Dezhou 251100,China;Institute of Interventional&Vascular Surgery,Tongji University,Shanghai 200072,China)

机构地区：[1]生物医用材料改性技术国家地方联合工程实验室,山东省德州市251100 [2]同济大学介入血管研究所,上海市200072

出　　处：《合成树脂及塑料》2018年第4期94-98,共5页China Synthetic Resin and Plastics

摘　　要：综述了聚ε-己内酯(PCL)药物控释材料的研究进展,以及PCL微球、PCL纳米微粒、PCL纤维、PCL薄膜、PCL胶束、PCL水凝胶的制备方法及应用。PCL在药物控释领域研究中,可通过与其他聚合物共混或共聚来改善亲水性和控释行为。PCL共聚物也可应用到靶向给药系统中,靶向给药系统不仅能够将药物输送至病灶部位,还能实现定向释放。随着新材料的不断研发,构建新型智能药物控释系统的前景将更加广阔。The research progress of poly(ε-caprolactone)(PCL)for drug controlled release were reviewed,which include the preparation and application of PCL microspheres,nanoparticles,fibers,films,micelles,and hydrogels.PCL can be blended or copolymerized with other polymers to improve hydrophilicity and controlled release behaviors of drugs.PCL can be applied to the targeted drug delivery system that not only conveys the drug to the lesion position but also realizes targeted release.With the research and development of new materials the novel intelligent drug controlled release system is being the emerging field.

关 键 词：可降解高分子 药物控释 药物载体 聚Ε-己内酯 靶向给药 

分 类 号：TQ323.8[化学工程—合成树脂塑料工业]