Intraretinal layer segmentation and parameter measurement in optic nerve head region through energy function of spatial-gradient continuity constraint  

基于空间连续性约束的视乳头区域视网膜内层次分割与参数测量（英文）

作　　者：CHEN Zai-liang WEI Hao SHEN Hai-lan PENG Peng YUE Ke-juan LI Jian-feng ZOU Bei-ji 陈再良;魏浩;沈海澜;彭鹏;岳珂娟;李建锋;邹北骥

机构地区：[1]School of Information Science and Engineering,Central South University [2]Joint Laboratory of Mobile Health,Ministry of Education and China Mobile [3]School of Information Science and Engineering,Jishou University

出　　处：《Journal of Central South University》2018年第8期1938-1947,共10页中南大学学报（英文版）

基　　金：Projects(61672542,61573380)supported by the National Natural Science Foundation of China

摘　　要：For the diagnosis of glaucoma,optical coherence tomography(OCT)is a noninvasive imaging technique for the assessment of retinal layers.To accurately segment intraretinal layers in an optic nerve head(ONH)region,we proposed an automatic method for the segmentation of three intraretinal layers in eye OCT scans centered on ONH.The internal limiting membrane,inner segment and outer segment,Bruch’s membrane surfaces under vascular shadows,and interaction of multiple high-reflectivity regions in the OCT image can be accurately segmented through this method.Then,we constructed a novel spatial-gradient continuity constraint,termed spatial-gradient continuity constraint,for the correction of discontinuity between adjacent image segmentation results.In our experiment,we randomly selected 20 B-scans,each annotated three retinal layers by experts.Signed distance errors of?0.80μm obtained through this method are lower than those obtained through the state-of-art method(?1.43μm).Meanwhile,the segmentation results can be used as bases for the diagnosis of glaucoma.光学相干断层扫描(OCT)是一种无创的成像技术,通常通过评估视网膜层的形态结构来诊断青光眼。为了准确分割视乳头(ONH)区域OCT图像中的视网膜内层次,提出一种自动分割视网膜内层次的方法。该方法能够在血管阴影、多个高反射区相互影响的情况下分割出ILM、IS-OS和BM。然后,构造出一种新的能量约束条件,称为空间连续性约束,用于修正相邻图像之间分割结果的不连续性。在实验中,随机选择20张图像,其中每张图像含有3条专家标定的分割线。相比较于目前最好算法–1.43μm的Signed误差,我们提出的方法获得了–0.80μm的Signed误差。同时,该分割结果能够为青光眼的诊断过程提供辅助信息。

关 键 词：surface segmentation parameter measurement optical coherence tomography optic nerve head spatial-gradient continuity constraints 

分 类 号：R816.97[医药卫生—放射医学]