基于整合药理学平台的六味地黄丸治疗糖尿病的分子机制研究  

On the Molecular Mechanism of Liuweidihuang Pillsin the Treatment of Diabetes Based on Integrated Pharmacology

作　　者：张佳琪 唐仕欢[2] 李德凤[2] 张毅[2] 苏瑾 刘杨[1] 张艾嘉 王萍[1,2] 王喜军 ZHANG Jiaqi;TANG Shihuan;LI Defeng;ZHANG Yi;SU Jin;LIU Yang;ZHANG Aijia;WANG Ping;WANG Xijun(Chinmedomics Research Center of State Administration of TCM,Heilongjiang University of Chinese Medicine,Harbin 150040,China;Institute of Chinese MateriaMedica,China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]黑龙江中医药大学国家中医方证代谢组学研究中心,哈尔滨150040 [2]中国中医科学院中药研究所,北京100700

出　　处：《复杂系统与复杂性科学》2018年第1期24-30,共7页Complex Systems and Complexity Science

基　　金：国家自然基金面上项目(81473584;81774201)

摘　　要：为探究六味地黄丸治疗糖尿病的潜在活性成分和作用机制,借助整合药理学平台对其药物靶标、基因功能和通路富集分析,运用整合药理学思维对六味地黄丸治疗糖尿病的分子机制进行研究。研究发现,多种代谢通路及成分靶点如PRKCB、GAA、GCK等与糖尿病相关联。推测六味地黄丸可通过调节氨基酸代谢、能量代谢及糖脂代谢等多种代谢紊乱来达到对糖尿病的治疗作用。To Explore the potential active ingredients and mechanism of action of Liuweidihuang Pills in the treatment of diabetesmellitus,with the help of integrated pharmacology platform for the analysis of drug targets,gene function and pathway enrichment.Then,the molecular mechanism of LiuweiDihuang Pill for the treatment of diabetes mellitus was studied by using integrated pharmacology thinking.The results showed that many metabolic pathways and components of the targets such as PRKCB,GAA,GCK were associated with diabetes mellitus.It has been speculated that Liuweidihuang Pills could regulate amino acid metabolism,energy metabolism and glucose metabolism and other metabolic disorders to achieve the therapeutic effect of diabetes mellitus.

关 键 词：六味地黄丸 糖尿病 整合药理学 分子机制 

分 类 号：R96[医药卫生—药理学]