望谟崖摩枝叶的化学成分及其抗炎活性研究  

Constituents from the Leaves and Twigs of Amoora ouangliensis and Their Anti-inflammatory Activities

作　　者：李金凤 许又凯 LI Jin-feng;XU You-kai(Key Laboratory of Tropical Plant Resources and Sustainable Use,Xishuangbanna Tropical Botanical Garden,Chinese Academy of Sciences,Menglun,Mengla,Yunnan 666303,People’s Republic of China;University of Chinese Academy of Sciences,Beijing 100049,People’s Republic of China)

机构地区：[1]中国科学院热带植物资源可持续利用重点实验室西双版纳热带植物园,勐腊勐仑666303 [2]中国科学院大学,北京100049

出　　处：《天然产物研究与开发》2018年第8期1361-1366,共6页Natural Product Research and Development

基　　金：热带民族药用植物资源的系统评价与普惠健康产品研发(2017XTBG-F02);中科院对外合作重点项目"一带一路"民族药与产业化合作(153631KYSB20160004)

摘　　要：为寻找传统药用植物望谟崖摩Amoora ouangliensis中的活性成分,采用色谱分离方法进行化合物分离,并通过波谱数据分析方法鉴定化合物的结构。从望谟崖摩枝叶中分得9个化合物,分别鉴定为cabralealactone(1)、cabraleahydroxylactone(2)、eichlerialactone(3)、金色酰胺醇酯(aurantiamide acetate)(4)、金色酰胺醇(benzenepropanamide)(5)、xylogranatinin(6)、丁香醛(7)、cycloartane-3β,24,25-triol(8)和24(R)-19-cyclolanost-3-one-24,25-diol(9)。在脂多糖诱导的RAW264.7细胞炎症模型中,化合物2~4和9显示出一定的活性。上述化合物均为首次从该植物中分得,化合物2~8为首次从该属植物中分得。To investigate the chemical constituents and anti-inflammation from the leaves and twigs of Amoora ouangliensis,we isolated and purified the constituents from A.ouangliensis by the chromatographic technique and Semi preparation HPLC.Nine compounds were isolated,their structures were identified as cabralealactone(1),cabraleahydroxylactone(2),eichlerialactone(3),aurantiamide acetate(4),benzenepropanamide(5),xylogranatinin(6),3,5-Dimethoxy-4-hydroxybenzaldehyde(7),cycloartane-3β,24,25-triol(8)and 24(R)-19-cyclolanost-3-one-24,25-diol(9).All of the isolates were then assessed for their anti-inflammatory activities on lipopolysaccharide(LPS)-induced nitric oxide(NO)production in RAW264.7.Compounds 2-4 and 9 showed protent anti-inflammatory activities.Compounds 1-9 were obtained from this plant for the first time and except compound 1,others are reported from the Amoora genus for the first time.

关 键 词：楝科 望谟崖摩 抗炎活性 

分 类 号：R284.1[医药卫生—中药学] Q94[医药卫生—中医学]