HepG2胰岛素抵抗细胞模型的诱导及其在生物活性评价中的应用  

The Application of HepG2 Insulin Resistance Cell Model in the Evaluation of Bioactivities

作　　者：宋皓 牛庆川 李玉萍 SONG Hao;NIU Qing-chuan;LI Yu-ping(School of Life Science,Jiangxi Science&Technology Normal University,Nanchang 330013,China)

机构地区：[1]江西科技师范大学生命科学学院,南昌330013

出　　处：《天然产物研究与开发》2018年第8期1469-1475,1468,共8页Natural Product Research and Development

基　　金：国家自然科学基金(31360376);江西省自然科学基金(20132BAB205091);江西科技师范大学研究生创新基金(YC2017-X38)

摘　　要：胰岛素抵抗是一种多因素诱发和多基因调控疾病。为了阐明胰岛素抵抗产生的机制,国内外学者建立了多种胰岛素抵抗细胞模型,其中HepG2肝癌细胞是应用较多的细胞模型。本文就HepG2肝癌细胞胰岛素抵抗模型的诱导方法及其在生物活性评价中的应用进行综述,以期为外周靶组织的胰岛素抵抗研究提供一定的理论参考。Insulin resistance is a multigene regulatory disease which also induced by multifactor.Researchers have established many kinds of insulin resistant cell model to clarify the mechanism of insulin resistance,including HepG2 cells which are a wide-accepted model cell.This review gives a detailed discussion on the research progress in establishment of insulin resistance HepG2cell model,as well as the evaluation of bioactivities in insulin resistance,providing a reference in improving insulin resistance.

关 键 词：HEPG2肝癌细胞 胰岛素抵抗 细胞模型 生物活性评价 

分 类 号：R96[医药卫生—药理学]