不同心率和地理环境因子与健康成年男性左室射血分数参考值的相关性  

Correlation of Heart Rate and Geographical Environmental Factors with Reference Values of Left Ventricular Ejection Fraction in Healthy Adult Males

作　　者：井静 葛淼 杨子祁 李鹏 韦德智 JING Jing;GE Miao;YANG Ziqi;LI Peng;WEI Dezhi(Institute of Health Geography,School of Geography and Tourism,Shaanxi Normal University, Xi’an 710119,China;Department of Geography,College of Geography and Environment,Baoji University of Arts and Sciences, Baoji,Shaanxi 721016,China)

机构地区：[1]陕西师范大学地理科学与旅游学院健康地理研究所,西安710119 [2]宝鸡文理学院地理与环境学院地理系,陕西宝鸡721016

出　　处：《中国医学科学院学报》2018年第4期487-492,共6页Acta Academiae Medicinae Sinicae

基　　金：国家自然科学基金(40971060);中央高校基本科研业务费专项资金(2016TS055)~~

摘　　要：目的研究健康成年男性左室射血分数(LVEF)参考值与心率和地理环境因子的关系,得出一种新的获取LVEF参考值的模型。方法收集2006至2016年中国3502例健康成年男性LVEF和心率(X_1)。采用相关分析和岭回归分析分别提取相关地理环境因子预测LVEF参考值。为揭示LVEF参考值的空间分布特征,使用地统计分析的Kriging插值。结果 LVEF与心率(X_1)及5项地理环境因子具有相关性。LVEF与心率(X_1)、纬度(X_3)、气温年较差(X_9)呈负相关;与年平均气温(X_6)、年平均相对湿度(X_7)、年降水量(X8)呈正相关。LVEF参考值与心率呈负相关。LVEF参考值与地理环境因子的岭回归方程为Y=68.464-0.0949X3-0.0619X6-0.00128X7+0.00069X8-0.0199X9±3.329。LVEF参考值与心率和地理环境因子的方程为Y=75.923-0.1035X_1-0.0958X_3-0.0741X_6+0.00094X_7+0.00081X_8-0.0211X_9±3.288。结论中国健康成年男性LVEF参考值分布呈现由南向北递减的趋势。若已知某一地区有关地理环境因子值,则可通过建立模型得到该地健康成年男性LVEF的参考值。新模型能够为医学制定LVEF参考值标准提供地域性依据。Objective To establish a model for obtaining the reference values of left ventricular ejection fraction(LVEF)in Chinese healthy adult males by exploring the relationships of these reference values with heart rate and geographical environment factors.Methods LVEF and heart rate reference values(X 1)were collected from 3502 healthy adult males from 2006 to 2016.Correlation analysis and ridge regression were employed to extract dependent geographical environment factors and predict the LVEF reference values.The Kriging interpolation was applied to reveal the spatial distribution of the LVEF reference values.Results LVEF and heart rate(X 1)were significantly correlated with five geographical environment factors.LVEF was negatively correlated with heart rate(X 1),latitude(X 3),and annual range of temperature(X 9)and positively correlated with annual mean air temperature(X 6),annual mean relative humidity(X 7),and annual precipitation amount(X 8).The reference values of LVEF had a negative correlation with heart rate.The ridge regression equation of LVEF reference values and geographical environment factors was as follows:Y=68.464-0.0949X 3-0.0619X 6-0.00128X 7+0.00069X 8-0.0199X 9±3.329.The equation of LVEF reference values with heart rate and geographical environment factors was Y=75.923-0.1035X 1-0.0958X 3-0.0741X 6+0.00094X 7+0.00081X 8-0.0211X 9±3.288.Conclusions The LVEF reference values among Chinese healthy adult males decreased from south to north.They can be determined based on the regression models after the geographical factors of a certain region are obtained.The new model offers a geographic basis for the establishment of LVEF reference values.

关 键 词：左室射血分数 参考值 心率 地区差异 地理环境因子 

分 类 号：R188[医药卫生—流行病学]