自噬与姜黄素抗肿瘤作用的关系  

Relationship between Autophagy and Curcumin-induced Anticancer Effect

作　　者：徐继明 丁浩然[1] 李质馨[1] 王弘珺[1] XU Jiming;DING Haoran;LI Zhixin;WANG Hongjun(Department of Histology and Embryology,Jilin Medical University,Jilin 132013,China)

机构地区：[1]吉林医药学院组织学与胚胎学教研室,吉林132013

出　　处：《中国医学科学院学报》2018年第4期568-572,共5页Acta Academiae Medicinae Sinicae

基　　金：吉林省科技厅自然科学基金(20130101140JC);吉林省大学生创新创业训练计划(2015)~~

摘　　要：姜黄素是从中药姜黄中提取的具有多种药理作用的多酚类物质。近年来,姜黄素的抗肿瘤作用已经成为研究热点之一。姜黄素在肿瘤细胞自噬中具有重要作用,主要通过磷酸腺苷激活的蛋白激酶-哺乳动物雷帕霉素靶蛋白、转录因子EB、Beclin-1/Bcl-2、内质网应激等信号通路调控自噬。由于自噬与凋亡之间存在复杂的交互作用,深入探讨姜黄素诱导自噬的机制以及姜黄素诱导自噬对肿瘤细胞凋亡的影响,将为姜黄素治疗肿瘤提供思路。Curcumin is a polyphenol extracted from turmeric rhizome and has multiple pharmacological roles.Recently,its anticancer properties have been recognized.Also,curcumin regulates autophagy in tumor cells via signaling pathways including AMP-activated protein kinase,mammalian target of rapamycin,transcription factor EB,Beclin-1,B-cell lymphoma 2,and endoplasmic reticulum stress.Considering the complicated crosstalk between autophagy and apoptosis,in this article we summaize the mechanism of curcumin-induced autophagy and its effect on apoptosis,with an attempt to provide insights on tumor therapy.

关 键 词：姜黄素 细胞自噬 细胞凋亡 

分 类 号：Q28[生物学—细胞生物学]