双贝胶囊的质量标准  

Quality Standard of Shuangbei Capsules

作　　者：权小英 马善波[2] 党碧艳[3] 缪珊[3] QUAN Xiaoying;MA Shanbo;DANG Biyan;MIAO Shan(The Bei Yuan-men Street of West Street Community Health Service Center in Xi'an Lianhu District,Xi'an 710000,China;Department of Pharmacy,Xijing Hospital the Fourth Military Medical University,Xi'an 710032,China;Institute of Materia Medica,the Fourth Military Medical University,Xi'an 710032,China)

机构地区：[1]西安市莲湖区北院门西大街社区卫生服务中心,西安710000 [2]第四军医大学西京医院药剂科,西安710032 [3]第四军医大学药物研究所,西安710032

出　　处：《医药导报》2018年第9期1111-1114,共4页Herald of Medicine

摘　　要：目的建立双贝胶囊的质量标准。方法采用薄层色谱法对双贝胶囊中土贝母、浙贝母、连翘进行定性鉴别;采用高效液相色谱法对双贝胶囊中土贝母苷甲进行定量分析。结果薄层色谱鉴别分离效果好,专属性强;土贝母苷甲含量在0.182~0.912 mg·m L-1范围内线性关系良好,r=0.9997;平均加样回收率99.31%,RSD 0.49%。结论该方法简单、准确、专属性强、重复性好,可有效控制双贝胶囊的质量。Objective To establish a quality standard of Shuangbei Capsules.Methods Fritillaria thunbergii,Fritillaria thunbergii Miq,Forsythia in Shuangbei capsules were identified by thin-layer chromatography(TLC).The content of tubeimoside I was determined by high performance liquid chromatography(HPLC).Results The characteristic identification by TLC was distinct and specific.There was a good liner relationship with contents of tubeimosideⅠin the ranges of 0.182-0.912 mg·mL-1 with good correlation coefficient r=0.9997.The average recovery was 99.31%and RSD was 0.49%.Conclusion The established methods are simple,accurate,exclusive,reproducible and suitable for the quality control of Shuangbei capsules.

关 键 词：双贝胶囊 土贝母苷甲 质量标准 色谱 薄层 色谱法 高效液相色谱 

分 类 号：R286[医药卫生—中药学] R927.11[医药卫生—中医学]