神经节苷脂钠治疗突发性耳聋临床疗效分析  

Clinical analysis of ganglioside sodium in the treatment of sudden deafness

作　　者：赵亚会 戴嵩 刘业军[3] Zhao Yahui;Dai Song;Liu Yejun(Jinzhou Medical University Graduate School,Jinzhou,Liaoning,121000,China;Liberation Army 463 Hospital Department of ENT,Shenyang,Liaoning,110000,China;Department of Otolaryngology,Qianjiang Central Hospital,Qianjiang,Hubei,433100,China)

机构地区：[1]锦州医科大学研究生院,辽宁锦州121000 [2]解放军463医院耳鼻喉科,辽宁沈阳110000 [3]潜江市中心医院耳鼻喉科,湖北潜江433100

出　　处：《当代医学》2018年第23期43-46,共4页Contemporary Medicine

摘　　要：目的探讨单唾液酸四己糖神经节苷脂钠对不同分型的突发性耳聋患者的临床疗效分析。方法对2015年7月~2016年10月在本院住院的435例突发性耳聋患者进行回顾性分析,详细询问病史,行体格检查,专科检查,辅助检查等。按患者住院对用药情况进行分组:其中常规药物记为A组,常规药物+单唾液酸四己糖神经节苷脂钠记为B组,常规药物+单唾液酸四己糖神经节苷脂钠+针灸记为C组;将各组疗效之间进行比较。对比不同方案治疗突发性耳聋的预后情况,然后将各组患者按听力类型分为低频下降型,高频下降型及平坦型,全聋型。将各分型之间疗效分别进行比较,对比不同分型治疗突发性耳聋预后情况。结果 A、B、C 3组不同方案治疗突发性耳聋的有效率分别为76.15%、88.15%、87.92%,差异有统计学意义(P<0.05):各组中不同分型之间疗效比较,差异有统计学意义(P<0.05)。结论常规药物联合单唾液酸四已糖神经节苷脂钠、针灸治疗突发性耳聋疗效最佳,低频下降型预后疗效最佳。单唾液酸四已糖神经节苷脂钠对高频听力下降突发性耳聋患者治疗有效率高于文献结果。Objective To investigate the clinical effect of mono-sialate tetrahexose ganglioside sodium in different types of sudden deafness.Methods 435 patients with sudden deafness who were hospitalized in our hospital from July 2015 to October 2016 were analyzed retrospectively.The history,physical examination,special examination and auxiliary examination were inquired into in detail.The patients were divided into three groups:group A,group B,group C acupuncture and moxibustion of mono-sialic acid tetrahexose ganglioside sodium,and routine drug mono-sialic acid tetrahexose ganglioside sodium were recorded as group A,group B and group C,respectively.The efficacy of each group was compared.Contrast different schemes.The prognosis of sudden deafness was treated.The patients in each group were divided into low frequency descending type,high frequency descending type and flat type according to hearing type.The curative effects of different types were compared to compare the prognosis of different types of treatment for sudden deafness.Results The effective rate of different regimens in the treatment of sudden deafness was 76.15%,88.15%and 88.15%,respectively(P<0.05).The difference was statistically significant(P<0.05),and the difference was statistically significant among the groups(P<0.05).Conclusion Conventional drugs combined with tetrahexose monosialate and sodium ganglioside,acupuncture and moxibustion.The treatment of sudden deafness is the best and the low frequency descending prognosis is the best.The effective rate of mono-tetrahexose ganglioside sodium in the treatment of high frequency hearing loss sudden deafness was higher than that in literature.

关 键 词：单唾液酸四已糖神经节苷脂钠 突发性耳聋 分型 治疗方案 

分 类 号：R764.437[医药卫生—耳鼻咽喉科]