β-内酰胺类抗生素的药物不良反应  

Adverse drug reactions of beta-lactam antibiotics

作　　者：金晓艳[1] Jin Xiaoyan(Department of Pharmacy,Guizhou Space Hospital 563003)

机构地区：[1]贵州航天医院药械科,563003

出　　处：《中国社区医师》2018年第25期10-11,共2页Chinese Community Doctors

摘　　要：目的:探讨β-内酰胺类抗生素的药物不良反应。方法:回顾性分析β-内酰胺类抗生素类所致药物不良反应患者158例的临床资料。结果:肌内注射给药后发生不良反应6例(3.8%),口服给药发生不良反应8例(5.1%),静脉滴注给药发生不良反应144例(91.1%)。β-内酰胺类抗生素的药物不良反应最易累及皮肤系统。头孢菌素类89例(56.3%)。结论:β-内酰胺类抗生素不良反应以皮肤系统为主,进行皮试可降低不良反应的发生。Objective:To investigate the adverse drug reactions(ADR)of beta-lactam antibiotics.Methods:The clinical data of 158 cases of patients with adverse drug reactions induced by beta-lactam antibiotics were analyzed retrospectively.Results:6 cases(3.8%)had adverse reactions after intramuscular injection,8 cases(5.1%)had adverse reactions after oral administration and 144 cases(91.1%)had adverse reactions after intravenous infusion.The adverse reactions of beta-lactam antibiotics were most involved in the skin system.Cephalosporins were found in 89 cases(56.3%).Conclusion:The adverse reactions of beta-lactam antibiotics were mainly skin system.The skin test was done to reduce the adverse reaction.

关 键 词：Β-内酰胺类抗生素 不良反应 指导用药 

分 类 号：R969.3[医药卫生—药理学]