基于离子通道的电化学传感技术研究进展  

Research Advances in Ion Channel-based Electrochemical Sensing Techniques

作　　者：姜晓晶 梁荣宁[1] 秦伟[1] JIANG Xiao-Jing;LIANG Rong-Ning;QIN Wei(Key Laboratory of Coastal Environmental Processes and Ecological Remediation,Yantai Institute of Coastal Zone Research(YIC),Chinese Academy of Sciences(CAS); Shandong Provincial Key Laboratory of Coastal Environmental Processes,YICCAS,Yantai 264003,China;University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]中国科学院海岸带环境过程与生态修复重点实验室和山东省海岸带环境过程重点实验室,中国科学院烟台海岸带研究所,烟台264003 [2]中国科学院大学,北京100049

出　　处：《分析化学》2018年第9期1350-1356,共7页Chinese Journal of Analytical Chemistry

基　　金：本文系国家自然科学基金项目(Nos.41576106,21475148)、中国科学院青年创新促进会人才项目(No.2014190)以及山东省泰山学者人才计划(No.TS20081159)资助。

摘　　要：近年来,基于离子通道的电化学检测技术备受关注,目前该技术已广泛应用于DNA测序、分子间相互作用测定以及无机离子、生物分子等检测中。本文从电化学检测方法的角度,综述了近年来基于离子通道的电流型、阻抗型以及电位型检测技术在化学与生物传感中的应用研究进展,重点介绍了此技术的作用原理及传感器构建方法,并对离子通道基电化学传感技术进行了展望。During the past few years,electrochemical sensing techniques based on ion channels have attracted considerable attention.Nowadays,these techniques have been widely used in DNA sequencing,measurement of molecular interactions and detection of inorganic ions and biological species.Hence,in this review,the research progresses of ion channel-based electrochemical techniques including amperometry,conductometry and potentiometry in chemical and biological sensing are addressed from the perspective of different electrochemical methods.The sensing mechanism and fabrication process of these sensing methods are mainly introduced.In addition,the further research orientations of electrochemical sensing based on ion channels are prospected.

关 键 词：离子通道 电化学检测技术 化学与生物传感 评述 

分 类 号：O657.1[理学—分析化学]