3D打印聚乳酸-左旋多巴复合骨替代材料的亲水性及力学性能  

Hydrophilic and mechanical properties of 3D printed polylactic levodopa as alternative material for bone regeneration

作　　者：郑晨 王明晓[1] 刘波[1] 张丽菊[2] 张娜[2] 王玉光[3] 王志强[3] Zheng Chen;Wang Ming-xiao;Liu Bo;Zhang Li-ju;Zhang Na;Wang Yu-guang;Wang Zhi-qiang(Department of Physiology,Zhuhai Campus of Zunyi Medical University,Zhuhai 519041,Guangdong Province,China;Department of Preventive Medicine,Zhuhai Campus of Zunyi Medical University,Zhuhai 519041,Guangdong Province,China;Department of Orthopedics,Affiliated Hospital of Logistics University of People’s Armed Police Force,Tianjin 300162,China)

机构地区：[1]遵义医学院珠海校区生理学教研室,广东省珠海市519041 [2]遵义医学院珠海校区预防医学教研室,广东省珠海市519041 [3]武警后勤学院附属医院骨科,天津市300162

出　　处：《中国组织工程研究》2018年第30期4800-4805,共6页Chinese Journal of Tissue Engineering Research

摘　　要：背景:传统的聚乳酸有机高分子材料存在细胞相容性较差、机械强度不足等问题。目的:评价3D打印新型聚乳酸-左旋多巴复合材料的力学性能及生物相容性。方法:采用3D打印技术制备聚乳酸支架材料(空白组);采用溶剂冷凝冻干挥发法在聚乳酸支架表面分别进行左旋多巴表面修饰(实验组)与无溶质修饰(对照组),检测3组支架的亲水角、耐压强度、抗弯强度及抗磨损能力。结果与结论:(1)空白组、实验组、对照组的亲水角分别为(89±5)°,(36±2)°,(87±4)°,实验组低于空白组、对照组(P<0.05);(2)空白组、实验组、对照组的最大抗压强度分别为142.3,149.4,140.6 N,实验组高于空白组、对照组(P<0.05);(3)空白组、实验组、对照组的最大抗弯曲力分别为55.8,95.7,56.7 N,实验组高于空白组、对照组(P<0.05);(4)在0-3 min内,实验组材料的摩擦系数、磨损体积最小;6 min后,各组材料摩擦系数趋近平行。实验组材料的磨损体积在实验3 min内最低,与其他两组比较差异有显著性意义,6 min后3组间磨损体积比较无差异;(5)结果表明,聚乳酸-左旋多巴复合材料具有优良的力学性能及生物相容性。BACKGROUND:There are some disadvantages in traditional polylactic organic polymer materials such as poor cell compatibility and insufficient mechanical strength.OBJECTIVE:To evaluate the mechanical properties and biocompatibility of 3D printed polylactic levodopa composites.METHODS:Polylactic scaffold materials were prepared by 3D printing technology(blank group);surface modifications(experimental group)and solute-free modifications(control group)were performed on the surface of polylactic scaffolds by solvent condensation and freeze drying volatilization method.In present study,the hydrophilic angle,compression strength,bending strength,and wear resistance of the above three groups were examined.RESULTS AND CONCLUSION:(1)The hydrophilic angles of the blank group,the experimental group and the control group were(89±5)°,(36±2)°,and(87±4)°,respectively,which was significantly less in the experimental group than the other two groups(P<0.05).(2)The maximum compressive strengths of the blank group,the experimental group,and the control group were 142.3 N,149.4 N,and 140.6 N,respectively,which was significantly higher in the experimental group than the other two groups(P<0.05).(3)The maximum bending resistance of the blank group,the experimental group,and the control group were 55.8 N,95.7 N,and 56.7 N,respectively,which was significantly higher in the experimental group than the other two groups(P<0.05).(4)Within 3 minutes,the friction coefficient and the wear volume of the experimental group were the smallest among the three groups;after 6 minutes,there was no significant difference in the friction coefficients among the three groups.The above results reveal that polylactic levodopa composites have excellent mechanical properties and biocompatibility.

关 键 词：复合材料 亲水角 左旋多巴 聚乳酸 摩擦系数 3D打印 生物材料 左旋多巴 接触镜 亲水性 生物力学 组织工程 

分 类 号：R318[医药卫生—生物医学工程]