人工血管研究现状与应用优势  

Current situation and development progress of vascular grafts

作　　者：严拓 刘雅文 吴灿 周峰 刘思诗 刘园 欧阳晨曦 Yan Tuo;Liu Ya-wen;Wu Can;Zhou Feng;Liu Si-shi;Liu Yuan;Ouyang Chen-xi(Wuhan Yangsen Biotechnology Co.,Ltd.,Wuhan 430079,Hubei Province,China;Department of Vascular Surgery,Fuwai Hospital,Chinese Academy of Medical Sciences,Beijing 100037,China)

机构地区：[1]武汉杨森生物技术有限公司,湖北省武汉市430079 [2]中国医学科学院阜外医院血管外科,北京市100037

出　　处：《中国组织工程研究》2018年第30期4849-4854,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家重点研发计划(2017YFC1104100)~~

摘　　要：背景:人工血管特别是小口径人工血管(内径≤4 mm)已成为国内外研究的热点。目的:综述目前市售的人工血管产品情况,并重点介绍人工血管领域的研究热点和技术方向。方法:作者以"vascular graft,vascular pro-tissue engineering;人工血管,组织工程"为关键词,检索2000至2018年期间CNKI、Sciencedirect、Web of Science、Springerlink等数据库中的相关文献。初检文章150篇,筛选后对52篇文章进行分析。结果与结论:目前的人工血管材料主要有动物源脱细胞基质、天然材料与高分子材料。为了进一步改善人工血管的性能与组织相容性,已将生物涂层技术、静电纺丝、组织工程等手段运用于人工血管领域,在抗血栓、抗组织增生、抗炎及提高远期通畅率等方面表现出巨大的优势。BACKGROUND:As one of the most important therapeutic methods of vascular diseases,vascular grafts,especially small-diameter vascular grafts(inner diameter≤4 mm),have become trends of research.OBJECTIVE:To review the states of commercial vascular grafts,and further introduce the research hotspot area and new technology development of vascular grafts.METHODS:A computer retrieval of CNKI,ScienceDirect,Web of Science and Springerlink databases was performed with“vascular graft,vascular pro-tissue engineering”as key words for relevant articles published from 2000 to 2018.Initially,150 articles were retrieved,and finally 52 articles were included in result analysis.RESULTS AND CONCLUSION:The commercial vascular grafts are mainly made of animal-derived acellular matrix,natural materials and polymer materials.For improving the clinical performance,new technologies,including bio-coatings,electrospinning and tissue engineering have been explored in the research of vascular grafts,which are considered as big advantages for antithrombus,anti-histogenesis and anti-inflammation as well as increasing long-term patency rate.

关 键 词：人工血管 膨体聚四氟乙烯 聚酯涤纶 生物涂层技术 静电纺丝技术 组织工程 生物材料 人工血管 生物相容性材料 组织工程 

分 类 号：R318[医药卫生—生物医学工程]