无抗凝连续性肾脏替代治疗在高危出血风险危重症患儿中的应用  

Application of non-anticoagulant continuous renal replacement therapy in children with high risk of bleeding

作　　者：薛志斌[1] 李映林[1] 张汉清 郑碧兰[1] XUE Zhibin;LI Yinglin;ZHANG Hanqing;ZHENG Bilan(Child Intensive Medicine,Putian Children’s Hospital,Putian Medical Group affiliated to Putian College,Fujian Putian 351100,China)

机构地区：[1]福建省莆田学院附属医院医疗集团莆田市儿童医院儿童重症医学科,福建莆田351100

出　　处：《上海医药》2018年第17期40-42,共3页Shanghai Medical & Pharmaceutical Journal

摘　　要：目的: 分析高危出血风险危重症患儿无抗凝连续性肾脏替代治疗(CRRT)的临床情况。方法: 对接受床旁CRRT治疗的危重症患儿的临床资料进行分析,比较治疗前后电解质、肾功能、酸碱、血小板、血红蛋白及凝血指标的变化情况。结果: 患儿治疗后尿素氮、血肌酐、乳酸、C反应蛋白、p H明显改善(P<0.05);凝血酶原时间、部分活化凝血活酶时间、白细胞、血红蛋白、血小板均无明显变化(P>0.05)。结论: 无抗凝CRRT可减少出血风险,高危出血风险危重症患儿应用该方案可取得满意效果。Objective:To analyze the clinical situation of non-anticoagulant continuous renal replacement therapy(CRRT)in children with high risk of bleeding.Methods:The clinical data from critically ill children who received a bedside CRRT treatment were analyzed,and the changes of indexes such as electrolytes,renal function,acid and alkali,platelet,hemoglobin and blood coagulation before and after the treatment were compared.Results:The levels of urea nitrogen,serum creatinine,lactic acid,C-reactive protein and the pH value were significantly improved after treatment(P<0.05).There were no significant changes in thrombin time,partial activation of thrombin,white blood cell count,hemoglobin and platelet levels(P<0.05).Conclusion:The risks of bleeding can be reduced by non-anticoagulant CRRT and satisfactory results can be achieved by the application of this therapy.

关 键 词：危重症 出血风险 无抗凝 连续性肾脏替代治疗 

分 类 号：R459.5[医药卫生—治疗学]