不同孕周梅毒干预治疗的妊娠结局meta分析  

In different gestational weeks treatment for syphilis about pegnancy outcome of meta-analyse

作　　者：谢晓绘[1] 张晓菊[1] 周丹[1] 黄小琴[1] XIE Xiaohui;ZHANG Xiaoju;ZHOU Dan;HUANG Xiaoqin(First People′s Hospital of Neijiang,Neijiang,Sichuan 641000,China)

机构地区：[1]内江市第一人民医院,四川641000

出　　处：《现代医药卫生》2018年第17期2652-2656,共5页Journal of Modern Medicine & Health

摘　　要：目的对不同孕周开始干预妊娠期梅毒的妊娠结局差异进行荟萃分析,确定最佳干预时机,以更好地预防梅毒母婴传播。方法计算机检索EMbase、Pub Med、The Cochrane Library、CNKI、万方数据库、VIP数据库,收集不同孕周妊娠期梅毒的干预治疗和妊娠结局分析数据,搜索时限均为建库至2017年7月。由2名研究者独立筛选文献、提取资料,应用Rev Man5.3软件进行meta分析。结果共纳入20篇文献,其中中文17篇,英文3篇,包括13 365例受试者。meta分析结果显示,妊娠早期干预与妊娠中期比较,先天梅毒的发生率更低,OR值为0.37[95%置信区间(CI)为0.27~0.50];妊娠中期干预与妊娠晚期比较,先天梅毒的发生率更低,OR值为0.14(95%CI为0.10~0.19),妊娠早期干预与妊娠晚期比较,先天梅毒的发生率更低,OR值为0.34(95%CI为0.27~0.42)。结论与妊娠中、后期进行筛查及治疗的产妇比较,妊娠早期进行筛查及治疗将更有可能拥有健康婴儿。为了达到有效的干预措施和更好的干预结局,产妇应早寻求产前保健。Objective Conduct a meta-analysis of the differences in pregnancy outcomes of gestational syphilis at dif-ferent gestational weeks,and determine the optimal intervention time to prevent mother-to-child transmission of syphilis better.Methods The computer retrieved EMbase,Pub Med,The Cochrane Library,CNKI,Wanfang database,VIP database,and collected the intervention treatment and pregnancy outcome analysis data of gestational syphilis in different gestational weeks.The search time was built until July 2017.Two researchers independently screened the literature,extracted the data,and per-formed meta-analysis using Rev Man5.3 software.Results A total of 20 articles were included,including 17 Chinese and 3 English,including 13 365 subjects.The meta-analysis showed that the incidence of congenital syphilis was lower in the early pregnancy intervention compared with the second trimester,with an OR of 0.37[95%confidence interval(CI)0.27-0.50].In the second trimester of pregnancy,the incidence of congenital syphilis was lower,with an OR of 0.14(95%CI 0.10-0.19).Ear-ly pregnancy intervention compared with late pregnancy,the incidence of congenital syphilis was lower,with an OR of 0.34(95%CI 0.27-0.42).Conclusion Screening and treatment in the early stages of pregnancy will be more likely to have healthy babies than those who are screened and treated in the second and third trimesters.In order to achieve effective interventions and better intervention outcomes,women should seek antenatal care early.

关 键 词：妊娠期梅毒 母婴传播 孕周 干预 不良妊娠结局 META分析 

分 类 号：R759.154[医药卫生—皮肤病学与性病学]