制马钱子粉急性毒性试验研究  

作　　者：董辉[1] 李先娜 何录文 南洋[1] 

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]黑龙江省中医药科学院中药研究院,黑龙江哈尔滨150036

出　　处：《湖南中医药大学学报》2018年第A01期47-47,共1页Journal of Hunan University of Chinese Medicine

基　　金：哈尔滨市应用技术研究与开发项目“基于代谢组学的马钱子毒性物质基础及毒性机理研究”(2014RFQXJ116)。

摘　　要：目的:探究经过烫制法研制出的可过筛75μm±4.1μm筛孔直径的制马钱子粉,其急性毒性的强度。措施:用通过国家安全标准检测的实验鼠做相关实验,运用随机分组方式对其进行分组,进行药物的灌输,而后对实验对象进行认真的视察,精准的记录其存活前的异常情况、丧生时间和丧生数量,用所得数据计算出该实验毒物的半数致死量。结果:实验测得用烫制法研制出的可过筛75μm±4.1μm筛孔直径的制马钱子的半数致死量为67.02毫克每千克,其半数致死量的百分之九十五的可信区间为[64.12,70.04]毫克每千克。结论:得出了用烫制法研制出可过筛75μm±4.1μm筛孔直径的制马钱子的致命性和致毒性,为以后的医学治疗增加了参考和依据。Objective:To explore the hot preparation method developed can screen 75 m+4.1 m diameter sieve Strychnos powder,the acute toxicity of strength.Measures:to do experiments with mice through the national security standards,grouping them by random grouping,drug infusion,and then the experimental subjects were carefully inspected,accurate records of the abnormal situation,the survival time and the number of killed were killed,with the data to calculate the half the poison the lethal dose.Results:the experiment was developed by hot method can screen 75 m+4.1 m diameter sieve Strychnos LD50 was 67.02 mg per kg,confidence interval,the LD50 of ninety-five percent mg/kg for[64.12,70.04].Conclusion:the development of a deadly Strychnos sieve 75 m+4.1 m sieve pore diameter and toxicity by boiling method,increase the reference and basis for future medical treatment.

关 键 词：毒性研究 制马钱子 实验研究 

分 类 号：R285.1[医药卫生—中药学]