左氧氟沙星治疗耐多药肺结核疗效与安全性分析  

作　　者：高燕[1] 

机构地区：[1]山东省济宁市结核病防治所,272000

出　　处：《湖南中医药大学学报》2018年第A01期858-858,共1页Journal of Hunan University of Chinese Medicine

摘　　要：目的:探究耐多药肺结核患者通过左氧氟沙星治疗后取得的临床成效。方法:选取某医院2015年1月-2016年6月治疗的耐多药肺结核患者80例,随机分为观察组和对照组各40人。两组均通过联合用药治疗,在此基础上,对照组运用氧氟沙星治疗,观察组运用左氧氟沙星治疗。治疗3、5个月后,针对痰菌转阴率、不良反应发生情况,对两组进行分析。结果:对照组痰菌转移率分别为60%、75%,观察组分别为80%、95%,观察组均高于对照组,(P<0.05);观察组不良反应发生率(7.5%)低于对照组(25%),(P<0.05)。结论:耐多药肺结核患者通过左氧氟沙星治疗后取得的临床成效显著,能够提高治疗效果,降低不良反应发生率。Objective:To explore the clinical efficacy of levofloxacin therapy in multidrug-resistant pulmonary tuberculosis patients.Methods:80 patients with MDR-TB admitted from January,2015 to June,2016 in our hospital were randomly divided into observation group and control group.The two groups were treated by combination therapy.On this basis,the control group was treated with ofloxacin and the observation group was treated with levofloxacin.After 3 and 5 months of treatment,the incidence of sputum negative rate and incidence of adverse reactions were analyzed.Results:The sputum transfer rate of the control group was 60%and 75%respectively,and the observation group was 80%and 95%respectively.The incidence of adverse reactions was 7.5%in the observation group.(P<0.05)(25%),respectively(P<0.05).Conclusion:The clinical efficacy of levofloxacin treatment in multidrug-resistant pulmonary tuberculosis patients is significant,which can improve the therapeutic effect and reduce the incidence of adverse reactions.

关 键 词：左氧氟沙星 肺结核 临床效果 安全性 

分 类 号：R972.4[医药卫生—药品]