溴己新联合纤维支气管镜肺泡灌洗对重症肺炎患者症状改善及血清相关免疫球蛋白、降钙素原水平变化的影响  

作　　者：冷凌涵[1] 

机构地区：[1]成都市第五人民医院,四川成都611130

出　　处：《湖南中医药大学学报》2018年第A01期1030-1032,共3页Journal of Hunan University of Chinese Medicine

摘　　要：目的:观察组溴己新联合纤维支气管镜肺泡灌洗治疗重症肺炎患者的临床疗效,及对患者临床症状、血清免疫球蛋白、降钙素原及相关炎性反应标志物表达水平的影响。方法:选取本院2012年6月~2017年6月间收治的92例重症肺炎患者作为观察资料,将入选患者以随机法均分后纳入对照组与观察组,对照组给予纤维支气管镜肺泡灌洗治疗,观察组在对照组治疗的基础上联合应用溴己新治疗;治疗二疗程后评估两组临床疗效;观察治疗前及治疗二疗程后两组患者动脉血气分析指标、血清免疫球蛋白水平、血清标志物表达水平的变化情况;治疗结束后统计并对比两组患者主要临床症状消失时间及住院时间。结果:观察组总有效率为91.30%,对照组总有效率为80.43%,观察组临床疗效整体优于对照组,P<0.05。治疗后两组各项血气分析指标均较前改善,P<0.05;治疗后观察组各项血气分析指标均优于对照组,P<0.05。治疗后两组血清免疫球蛋白均较前改善,P<0.05;治疗后观察组各项血清免疫球蛋白水平均优于对照组,P<0.05。治疗后两组血清标志物:降钙素原、C反应蛋白均较前改善,P<0.05;治疗后观察组各项血清标志物表达水平均优于对照组,P<0.05。观察组咳嗽咳痰、哮鸣音、湿罗音、发热、肺部阴影的消失时间及住院时间均短于对照组,P<0.05。结论:溴己新联合纤维支气管镜肺泡灌洗治疗重症肺炎疗效理想,可促使主要症状症状尽早恢复,改善血清免疫球蛋白、降钙素原及C反应蛋白的表达水平。Objective:To observe the clinical efficacy of bromhexine combined with bronchoscopy and bronchoalveolar lavage in the treatment of patients with severe pneumonia and its clinical symptoms,serum immunoglobulin,procalcitonin and the expression of related inflammatory factors.Methods:Seventy-two patients with severe pneumonia admitted from June 2012 to June 2017 in our hospital were selected as observation data.The patients were randomly divided into control group and observation group.The control group was given bronchoscopic alveolar perfusion The patients in the observation group were treated with bromhexine on the basis of the treatment of the control group.The clinical efficacy of the two groups was evaluated after the second course of treatment.The arterial blood gas analysis indexes,serum immunoglobulin levels,Serum markers changes in the level of the situation;after treatment statistics and comparison of two groups of patients the main clinical symptoms disappear time and hospital stay.Results:The total effective rate was 91.30%in the observation group and 80.43%in the control group.The overall clinical efficacy in the observation group was better than that in the control group(P<0.05).After treatment,the two groups of blood gas analysis indicators were improved compared with the previous,P<0.05;after treatment,all the blood gas analysis indicators were better than the control group,P<0.05.After treatment,serum immunoglobulin in both groups improved compared with the previous group,P<0.05;serum immunoglobulin levels in observation group were better than those in control group after treatment(P<0.05).Serum markers of procalcitonin and proinflammatory cytokines were improved after treatment in both groups(P<0.05).The levels of serum markers in the observation group were all better than those in the control group(P<0.05).The observation group cough and sputum,wheezing,wet rales,fever,disappearance of lung shadow and hospital stay were shorter than the control group,P<0.05.Conclusion:Bromelain combined with bron

关 键 词：重症肺炎 纤维支气管镜 肺泡灌洗 免疫球蛋白 炎性反应标志物 

分 类 号：R563.1[医药卫生—呼吸系统]