“双固一通”针刺法配合中药治疗血管性痴呆的临床研究  

Clinical Study of ShuangGu Yi Tong Needling plus Chinese Medication for Vascular Dementia

作　　者：冯美果 刘翠芳[1,2] 陈莉 郑刚[1,2] 杨茜 FENG Mei-guo;LIU Cui-fang;CHEN Li;ZHENG Gang;YANG Qian(Hubei Xianning Central Hospital,Xianning 437000,China;The First Affiliated Hospital of Hubei University of Science and Technology,Xianning 437000,China)

机构地区：[1]湖北省咸宁市中心医院,咸宁437000 [2]湖北科技学院附属第一医院,咸宁437000

出　　处：《上海针灸杂志》2018年第9期982-986,共5页Shanghai Journal of Acupuncture and Moxibustion

基　　金：湖北省中医药中西医结合科研课题(2008Z-Y38);咸宁市高层次人才科研项目择优资助课题(咸人[2009]70号)

摘　　要：目的观察"双固一通"针刺法配合中药治疗血管性痴呆的临床疗效。方法将300例血管性痴呆患者随机分为西药组、中药组和针药组,每组100例。西药组给予西药治疗,中药组给予中药治疗,针药组在中药组治疗基础上给予"双固一通"针刺。观察3组治疗前后氧化应激指标[超氧化物歧化酶(SOD)、血浆脂质过氧化物(LOP)、血脂指标[总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)]、血液流变学指标(全血黏度、血浆黏度、红细胞压积、纤维蛋白原含量)的变化和治疗中的不良反应情况,并比较临床疗效。结果针药组总有效率为91.0%,显著高于西药组的79.0%和中药组的77.0%(P<0.05)。3组治疗后SOD水平较治疗前均显著上升(P<0.05),LOP水平较治疗前均显著下降(P<0.05);针药组治疗后SOD水平均显著高于西药组和中药组(P<0.05),LOP水平显著低于西药组和中药组(P<0.05);西药组与中药组治疗后的SOD和LOP水平比较,差异无统计学意义(P>0.05)。3组治疗后TC、TG、LDL-C水平较治疗前均显著下降(P<0.05),且针药组各项水平均显著低于西药组和中药组(P<0.05),西药组与中药组比较差异无统计学意义(P>0.05)。3组治疗后全血黏度、血浆黏度、红细胞压积、纤维蛋白原含量较治疗前均显著下降(P<0.05),且针药组各指标水平均显著低于西药组和中药组(P<0.05),西药组与中药组比较差异无统计学意义(P>0.05)。3组均无显著不良反应发生。结论 "双固一通"针刺法配合中药治疗血管性痴呆效果明显,能够改善患者抗氧化功能,降低血脂水平。Objective To observe the clinical efficacy of Shuang Gu Yi Tong needling(an acupuncture method to both tonify and unblock)plus Chinese medication in treating vascular dementia(VD).Method A total of 300 VD patients were randomized into a Western medication group,a Chinese medication group and an acupuncture-medication group,with 100 cases in each group.The Western medication group was intervened by Western medication,the Chinese medication group was given Chinese medication,while the acupuncture-medication group was intervened by Shuang Gu Yi Tong needling in addition to the same Chinese medication.The oxidative stress indexes[superoxide dismutase(SOD)and lipid peroxide(LOP)],blood lipid indexes[total cholesterol(TC),triglyceride(TG)and low density lipoprotein cholesterol(LDL-C)],and hemorheology indexes(whole blood viscosity,plasma viscosity,hematocrit and fibrinogen)were observed before and after the treatment in the three groups,as well as the adverse reactions occurred during the treatment.The clinical efficacies were compared.Result The total effective rate was 91.0%in the acupuncture-medication group,significantly higher than 79.0%in the Western medication group and 77.0%in the Chinese medication group(P<0.05).In the three groups,the level of SOD increased(P<0.05)and the level of LOP dropped(P<0.05)after the treatment.After the treatment,the level of SOD in the acupuncture-medication group was higher than that in the Western medication group and the Chinese medication group(P<0.05),and its level of LOP was lower than the level in the other two groups(P<0.05);there were no significant differences in the SOD and LOP levels between the Western medication group and the Chinese medication group(P>0.05).The levels of TC,TG and LDL-C dropped after the treatment in the three groups(P<0.05),and the levels in the acupuncture-medication group were lower than the levels in the Western medication group and the Chinese medication group(P<0.05),while the difference between the Western medication group and the Chinese medic

关 键 词：针刺疗法 针药并用 痴呆 血管性 双固一通 中药 

分 类 号：R246.6[医药卫生—针灸推拿学]