穴位贴敷配合滋肾通淋方治疗女性再发性尿路感染疗效观察  

Observation on the Efficacy of Acupoint Application plus Zi Shen Tong Lin Decoction in Treating Female Recurrent Urinary Tract Infections

作　　者：应汝炯 胡粤杭 盛昭园 吴婉静 陈建 何立群[2] YING Ru-jiong;HU Yue-hang;SHENG Zhao-yuan;WU Wan-jing;CHEN Jian;HE Li-qun(Shanghai TCM-integrated Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200082,China;Shuguang Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200021,China)

机构地区：[1]上海中医药大学附属上海市中西医结合医院,上海200082 [2]上海中医药大学附属曙光医院,上海200021

出　　处：《上海针灸杂志》2018年第9期1037-1041,共5页Shanghai Journal of Acupuncture and Moxibustion

基　　金：上海市进一步加快中医药事业发展三年行动计划(ZY3-LCPT-1-1006;ZY3-FWMS-2-1014);上海市名老中医--何立群学术经验研究工作室建设项目(SHGZS-2017027);上海市虹口区卫生和计划生育委员会医学科研项目(虹卫1404-09)

摘　　要：目的观察固元膏穴位贴敷配合滋肾通淋方治疗女性阴阳两虚、湿热下注型再发性尿路感染的临床疗效。方法将90例女性阴阳两虚、湿热下注型再发性尿路感染例患者随机分为治疗组和对照组,每组45例。两组均采用常规抗感染治疗,治疗组在此基础上采用固元膏穴位贴敷配合滋肾通淋方治疗,对照组采用口服宁泌泰胶囊治疗。治疗12周后,观察两组治疗前后中医证候积分及肾小管功能各项指标[尿a1-微球蛋白(a1-MG)、尿b2-微球蛋白(b2-MG)、尿N-乙酰-b-D-葡萄糖苷酶(NAG)、尿视黄醇结合蛋白(RBP)]的变化情况,并比较两组临床疗效及中医证候疗效。结果治疗组临床疗效总有效率及中医证候总有效率分别为90.9%和93.2%,对照组分别为68.3%和61.0%,两组比较差异均具有统计学意义(P<0.01)。两组治疗后中医证候积分与同组治疗前比较,差异均有统计学意义(P<0.01)。治疗组治疗后肾小管功能各项指标(尿a1-MG、尿b2-MG、尿NAG、尿RBP)与同组治疗前比较,差异均有统计学意义(P<0.01,P<0.05)。对照组治疗后尿RBP与同组治疗前比较,差异有统计学意义(P<0.01)。治疗组治疗后中医证候积分及尿a1-MG、尿NAG与对照组比较,差异均有统计学意义(P<0.01)。结论固元膏穴位贴敷配合滋肾通淋方治疗女性阴阳两虚、湿热下注型再发性尿路感染染疗效确切,能改善患者临床症状,保护患者肾小管功能。Objective To investigate the clinical effect of acupoint application with Gu Yuan paste plus Zi Shen Tong Lin decoction in treating female recurrent urinary tract infections due to qi-yin deficiency and downward flow of damp heat.Method Ninety female patients with recurrent urinary tract infections due to qi-yin deficiency and downward flow of damp heat were randomized to observation and control groups,with 45 cases in each group.Both group received conventional anti-infection treatment.In addition,the treatment group was intervened by acupoint application with Gu Yuan paste plus Zi Shen Tong Lin decoction,while the control group was treated with oral administration of Ning Mi Tai capsules.Before and after 12-week treatment,the traditional Chinese medicine(TCM)symptom score and indicators of tubular function[urinaryα1-microglobulin(α1-MG),urinaryβ2-microglobulin(β2-MG),urinary N-acetyl-β-D-glucosaminidase(NAG)and Urinary retinol binding protein(RBP)]in the two groups were observed,and the clinical efficacies and efficacies in improving the TCM symptoms were compared.Result The total effective rate and the total effective rate in improving the TCM symptoms were respectively 90.9%and 93.2%in the treatment group versus 68.3%and 61.0%in the control group,and the between-group differences were statistically significant(P<0.01).The TCM symptom score showed a significant change after the treatment in the two groups(P<0.01).There were statistically significant changes in the indicators of tubular function(urinaryα1-MG,urinaryβ2-MG,urinary NAG and urinary RBP)after the intervention in the treatment group(P<0.01,P<0.05).Urinary RBP changed significantly after the treatment in the control group(P<0.01).After the treatment,the TCM symptom score and the indicators of urinaryα1-MG and urinary NAG in the treatment group were significantly different from those in the control group(P<0.01).Conclusion Acupoint application with Gu Yuan paste plus Zi Shen Tong Lin decoction can produce valid efficacy in treating female recur

关 键 词：穴位贴敷法 尿路感染 再发性 尿Α1-微球蛋白 尿Β2-微球蛋白 尿N-乙酰-β-D-葡萄糖苷酶 尿视黄醇结合蛋白 针药并用 

分 类 号：R246.1[医药卫生—针灸推拿学]