急性ST段抬高型心肌梗死患者血浆miR-1、miR-146b的表达及临床意义  

Expression and clinical significance of plasma miR-1 and miR-146b of patients with acute ST-segment elevation myocardial infarction

作　　者：陈其敬 罗江宾 张云波 陈林 CHEN Qijing;LUO Jiangbin;ZHANG Yunbo;CHEN Lin(Sanya People's Hospital,Sanya 572000,China)

机构地区：[1]三亚市人民医院,海南三亚572000

出　　处：《山东医药》2018年第33期17-20,共4页Shandong Medical Journal

基　　金：海南省卫生计生行业科研项目(1602320366A2001)

摘　　要：目的探讨急性ST段抬高型心肌梗死(STEMI)患者血浆miR-1、miR-146b的表达及临床意义。方法选择STEMI患者79例(观察组)和非STEMI胸痛患者59例(对照组),两组性别、年龄、高血压史、糖尿病史、吸烟史构成及BMI、收缩压、舒张压及TC水平比较差异无统计学意义(P均>0.05)。检测两组血浆肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白I(cTnI)水平以及观察组入院时(T0)、入院12 h(T1)、24 h(T2)、48 h(T3)、7 d(T4)血浆miR-1、miR-146b表达情况。结果观察组血浆CK-MB、cTnI表达水平高于对照组(P均<0.05)。与对照组相比,观察组T0、T1、T2及T3时血浆miR-1、miR-146b表达水平均升高(P均<0.05)。观察组在T1时血浆miR-1、miR-146b表达水平最高,与其他时间点比较差异有统计学意义(P均<0.05)。STEMI患者血浆miR-1、miR-146b表达水平与CK-MB、cTnI水平及冠脉造影评分呈正相关(P均<0.05)。结论 STEMI患者血浆miR-1、miR-146b表达水平升高,有望成为STEMI诊断和治疗的新靶点。Objective To explore the expression and clinical significance of plasma miR-1 and miR-146b in patients with acute ST-segment elevation myocardial infarction(STEMI).Methods Seventy-nine cases of STEMI patients(observation group)and 59 cases of patients with non-STEMI chest pain(control group)were selected.There was no significant difference in gender,age,history of hypertension,history of diabetes,smoking history,BMI,systolic blood pressure,diastolic blood pressure or TC levels between the two groups(all P>0.05).The levels of creatine kinase isoenzyme(CK-MB)and cardiac troponin I(cTn I)in the two groups were measured,and the expression of plasma miR-1 and miR-146b in the two groups at the time of on admission(T0)and at 12 h(T1),24 h(T2),48 h(T3),and 7 d(T4)after admission was detected.Results The plasma levels of CK-MB and cTnI in the observation group were higher than those in the control group(all P<0.05).The expression levels of plasma miR-1and miR-146b in patients with STEMI at T0,T1,T2 and T3 was significantly higher than those of the control group(all P<0.05).The levels of plasma miR-1 and miR-146b were the highest at T1,and there was a statistically significant difference in comparison with other time points(P<0.05).The expression levels of plasma miR-1 and miR-146b in STEMI patients was positively correlated with CK-MB,cTnI and coronary angiography score(all P<0.05).Conclusion The elevated level of miR-1 and miR-146b in STEMI patients is expected to become a new target for STEMI diagnosis and treatment.

关 键 词：心肌梗死 急性ST段抬高型 MIR-1 miR-146b 肌酸激酶同工酶 心肌肌钙蛋白I 

分 类 号：R542.2[医药卫生—心血管疾病]