氨基质子饱和转移效应MRI技术研究进展  

Research progresses of amide proton transfer MRI techniques

作　　者：黄振宇[1] 李武铭[1] 江桂华[1] HUANG Zhenyu;LI Wuming;JIANG Guihua(Department of Medical Imaging,Guangdong No.2 Provincial People's Hospital,Guangzhou 510317,China)

机构地区：[1]广东省第二人民医院影像科,广东广州510317

出　　处：《中国医学影像技术》2018年第9期1422-1425,共4页Chinese Journal of Medical Imaging Technology

摘　　要：近年来,氨基质子饱和转移MRI(APT-MRI)技术在动物实验与临床研究中均取得突破性成果,促进了APT-MRI序列的改进和成像设备的更新。APT-MRI可探测内源性游离蛋白质和缩氨酸含量,临床用于诊断脑肿瘤、脑卒中等疾病。本文针对APT-MRI技术的关键点,对其成像基本原理、序列发展和序列改进特点、数据采集方法和临床运用以及未来发展和研究趋势进行综述。In recent years,amide proton transfer MRI(APT-MRI)technology has made a breakthrough in animal experiments and clinical applications,which promoted the improvement of APT-MRI sequences and the updating of imaging equipments.APT-MRI has an advantage in detecting endogenous free protein and peptides content,and is clinically applied to the diagnosis of diseases such as brain tumors and stroke.Focusing on the key point of APT-MRI technology,the basic principles of imaging,the development of imaging sequences and the characteristics of sequence improvement,data acquisition methods,clinical application and future development were reviewed in this article.

关 键 词：磁共振成像 氨基质子饱和转移 成像序列 水脂分离 

分 类 号：R445.2[医药卫生—影像医学与核医学]