儿茶酚胺抑素对急性心梗大鼠室性心律失常的影响  

Effect of catestatin on ventricular arrhythmia in acute myocardial infarction in rats

作　　者：方媛[1] 舒娟[1] 刘洋[1] 曹瑜梦 FANG Yuan;SHU Juan;LIU Yang;Cao Yu-meng(Department of Cardiovascular Medicine,The First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China)

机构地区：[1]西安交通大学第一附属医院心内科,陕西西安710061

出　　处：《西安交通大学学报（医学版）》2018年第5期644-647,共4页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：国家自然科学基金资助项目(No.30900616)~~

摘　　要：目的探讨儿茶酚胺抑素(CST)和急性心梗室性心律失常之间的关系。方法雄性SD大鼠60只,随机分为假手术组(n=20)和心梗组(n=40),结扎冠状动脉制备心梗模型,心梗组存活36只。测量大鼠血浆CST水平,使用程序性电刺激法评估急性心肌梗死时心肌室性心律失常的易患率,同时测定在不同频率和强度的电刺激下,鼠心室肌的易损期时间窗和有效不应期的变化。了解CST对急性心梗大鼠室性心律失常的影响。结果与假手术组相比,心梗组左室射血分数(LVEF)明显减小(P<0.01),而左室舒张末内径(LVEDD)和左室收缩末内径(LVESD)则明显增大(P<0.01),CST明显升高(P<0.01);程序性电刺激后,假手术组未能诱发室性心律失常,心肌梗死组共31只(86.1%)大鼠诱发出室性心律失常(P<0.01);心梗组大鼠固定强度心室易损期时间窗延长、有效不应期缩短(P<0.01)。Logistic回归分析显示,LVEF降低和CST升高均为急性心梗室性心律失常的独立危险因素(P<0.05,P<0.01)。结论 CST升高是急性心肌梗死室性心律失常发生的独立危险因素,是可用于预测急性心梗的预后指标之一。Objective To explore the correlation between the catestatin(CST)level and ventricular arrhythmia(VA)in acute myocardial infarction(AMI).Methods Sixty male rats were randomly divided into sham group(n=20)and AMI group(n=40).Myocardial infarction was produced by ligation of the left anterior descending coronary artery.Thirty-six rats in AMI groupsurvived.Both groups were detected for plasma CST level,ventricular arrhythmia susceptibility,ventricular vulnerable period and effective refractory period so as to evaluate the effect of CST on VA in AMI.Results Compared with that in sham group,LVEF reduced significantly in AMI group(P<0.01),while LVEDD,LVESD and CST increased(P<0.01).After programmed electrical stimulation,in AMI group VA was induced in 31 rats(86.1%)(P<0.01),ventricular vulnerable period extended,and effective refractory period shortened(P<0.01).Logistic regression analysis showed that decreased LVEF and increased CST were the independent risk factors of VA in AMI rats(P<0.01 to P<0.05).Conclusion The CST level is an independent risk factor for VA in AMI;therefore,it can be used to evaluate the prognosis of AMI.

关 键 词：急性心梗 儿茶酚胺抑素 室性心律失常 心室易损期 有效不应期 

分 类 号：R541.4[医药卫生—心血管疾病]