呋噻米与^(18)F-FDG同时注射对PET/CT诊断泌尿系统及盆腔病变显示率的影响  

Effect of simultaneous injection of furosemide and ^(18)F-FDG on the diagnosis of urinary system and pelvic lesions by PET/CT

作　　者：李林娟 尹吉林[2] 赵菁[2] 周文彬[2] 王瑞敏 全江涛[2] 张俊 王欣璐[1] LI Linjuan;YIN Jilin;ZHAO Jing;ZHOU Wenbin;WANG Ruimin;QUAN Jiangtao;ZHANG Jun;WANG Xinlu(Guangdong Pharmaceutical University,Guangzhou 510000,China)

机构地区：[1]广东药科大学,广州510000 [2]广州军区广州总医院PET/CT中心PET/CT,广州510010

出　　处：《实用医学杂志》2018年第17期2954-2957,共4页The Journal of Practical Medicine

摘　　要：目的采取将同时注射法(即注射18F-FDG后即静脉注射呋噻米的方法)与常规分次注射法(即先静脉注射18F-FDG 1.5 h后再静脉注射呋噻米)进行对照,探究两种方法 PET/CT对泌尿系统及盆腔病变显示的影响,总结出达到最佳诊断效能的呋噻米注射方法。方法回顾性对比分析行呋噻米介入的PET/CT全身显像的患者,依据病理及临床随访结果分析两组患者泌尿系统及盆腔病灶图像上的差异,总结两种方法的优缺点。结果两组方法对病变促排有效率均为100%;为达到诊断目的,同时注射组和分次注射组进行常规、双时项、三时项显像者分别占59.4%、37.5%、3.1%和0、92.1%、7.9%;同时注射组和分次注射组患者平均检查总时长分别为2.8和4.6 h。两组患者膀胱及周围组织病灶(包括子宫及附件、直肠、输尿管)SUVmax与尿液SUVmax差异无统计学意义。结论同时静脉注射的方法较常规分次注射的方法具有以下优点:简化检查的流程,减少机位占用、患者检查以及工作人员受放射性照射时间,减少患者CT辐射剂量。18F-FDG与呋噻米同时注射的方法比常规分次注射法具有一定的优势,值得进一步推广使用和用更大病例样本的验证。Objective To compare the effect of simultaneous intravenous injection of 18F-FDG and furosemide and conventional fractional injection(intravenous injection of 18F-FDG first,and then intravenous injection of furosemide after 1.5 h)on showing the urinary system and pelvic lesions by PET/CT and to summarize the best diagnostic efficacy of furosemide injection method.Methods The patients undergoing furosemide interventional PET/CT whole body imaging had been retrospectively analyzed.According to the results of pathological and clinical follow-up,the image differences about urinary system and pelvic lesions in the two groups had been analyzed,then the merits and drawbacks of the two methods had been summarize.Results The effective rate of the 2 injection methods were both 100%.Conventional imaging,two-phase imaging and three-phase imaging in simultaneous injection group and fractional injection group were 59.4%,37.5%and 3.1%and 0,92.1%and 7.9%,respectively.The mean total scan time was 2.8 h and 4.6 h respectively.There was no significant difference between SUVmax of bladder and surrounding tissue lesions and urine SUVmax between the two methods.Conclusion Simultaneous intravenous injection of 18F-FDG and furosemide has some advantages over conventional fractional injection,such as simplifying inspection process,reducing scanner occupancy time and total inspection time and reducing the radioactive irradiation and the amount of CT radiation patients received.It is worthy of further promotion but needs to be verified by a larger number of cases.

关 键 词：呋噻米 诊断 PET/CT 脱氧葡萄糖 延迟扫描 

分 类 号：R817.4[医药卫生—影像医学与核医学] R691[医药卫生—放射医学]