MicroRNA参与调控睾丸支持细胞的增殖与粘附功能  

MicroRNA regulates Sertoli cell proliferation and adhesion

作　　者：夏蒙蒙 申雪沂 牛长敏 夏静[1] 孙红亚[1] 郑英[1] Mengmeng Xia;Xueyi Shen;Changmin Niu;Jing Xia;Hongya Sun;Ying Zheng(Department of Histology and Embryology,School of Medicine,Yangzhou University,Yangzhou 225001,China)

机构地区：[1]扬州大学医学院组织学与胚胎学教研室,扬州225001

出　　处：《遗传》2018年第9期724-732,共9页Hereditas（Beijing)

基　　金：国家自然科学基金项目(编号:31371174);江苏省自然科学基金项目(编号:BK20131230)资助~~

摘　　要：精子发生过程需要生精细胞及睾丸体细胞的共同参与,这两种细胞也决定着睾丸的发育及雄性生育力。支持细胞是生精小管中唯一的体细胞,在正常精子发生过程中发挥重要的作用。支持细胞增殖与粘附功能的异常将导致精子发生异常,进而引发雄性不育。近年来研究发现,micro RNA(mi RNA)可调控支持细胞的增殖与粘附功能,其表达水平在激素、内分泌干扰素和营养状况等多种因素作用下发生特异性变化。本文总结了与睾丸支持细胞增殖与粘附功能相关的mi RNA及其作用机制,以期发现并鉴定更多与支持细胞相关的mi RNA,进而为探索与支持细胞相关不育症的病因提供理论依据。Spermatogenesis requires both germ cells and testicular somatic cells,which are also involved in testicular development and male fertility.Sertoli cells are the only somatic cells in the seminiferous tubules and play very important roles in normal spermatogenesis.Abnormality of Sertoli cells in proliferation and adhesion may induce aberrant spermatogenesis and eventually cause infertility.Recently,various studies have demonstrated that miRNA are involved in the regulation of Sertoli cell proliferation and adhesion.Additionally,miRNA expression could be affected by hormone,endocrine interferon,and nutrition.In this review,we summarize miRNAs related to Sertoli cell proliferation and adhesion,which will be helpful for finding and identifying more miRNAs from Sertoli cells.The review will also provide theoretical basis for the pathogenesis of infertility associated with Sertoli cells.

关 键 词：MIRNA 支持细胞 增殖 粘附 

分 类 号：R321.1[医药卫生—人体解剖和组织胚胎学]