铜绿假单胞菌耐药机制研究进展  

Research progress in drug resistance mechanism of pseudomonas aeruginosa

作　　者：孙磊 尹延青 李睿超 张敏敏 吴记勇[1] 纪宏志[1] Sun Lei;Yin Yanqing;Li Ruichao;Zhang Minmin;Wu Jiyong;Ji Hongzhi

机构地区：[1]山东大学附属省立医院药剂科,济南250022

出　　处：《国际医药卫生导报》2018年第18期2727-2732,共6页International Medicine and Health Guidance News

摘　　要：铜绿假单胞菌作为重要的条件致病菌,在人体内分布广泛,是引起医院感染的主要病原菌之一。铜绿假单胞菌对临床常用抗菌药物,如碳青霉烯类、氨基糖苷类及喹诺酮类等有较强耐药性,给临床治疗带来困难。本文综述铜绿假单胞菌对以上三类抗菌药物的主要耐药机制,为临床合理选择抗菌药物提供参考,以达到降低细菌耐药性的目的。Pseudomonas aeruginosa widely distributes in the human skin,intestine,respiratory tract.It is an important pathogenic bacteria and one of the main pathogenic bacteria causing the hospital infectio.Currently,pseudomonas aeruginosa has strong resistance to the clinical use of antimicrobial agents,suchas carbapenems,aminoglycoside,and quinolones,which can make clinical treatment difficult.This reviewsummarizes the main resistance mechanisms of Pseudomonas aeruginosa to the above three kinds of antimicrobialagents,so as to provide some references for clinical rational selection of antibacterial agents and reduce theresistance of bacteria.

关 键 词：铜绿假单胞菌 耐药机制 碳青霉烯类 氨基糖苷类 喹诺酮类 

分 类 号：R378[医药卫生—病原生物学]