血清簇集蛋白水平与冠心病的关系研究  

Relationship between Serum Clusterin Level and Coronary Heart Disease

作　　者：吴耀杰 徐林[2] 陈玺宇 范稣圳 WU Yao-jie;XU Lin;CHEN Xi-yu;FAN Su-zhen(Department of Cardiovascular Medicine,the People's Hospital of Yunmeng County,Xiaogan,Xiaogan 432500,China;Department of Cardiology,the People's Hospital of Wuhan University(Institute of Cardiology,Wuhan University&Hubei Key Laboratory of Cardiovascular Diseases),Wuhan 430060,China)

机构地区：[1]湖北省孝感市云梦县人民医院心血管内科,432500 [2]武汉大学人民医院心内科,武汉大学心血管病研究所,心血管病湖北省重点实验室,湖北省武汉市430060

出　　处：《实用心脑肺血管病杂志》2018年第7期26-29,共4页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：国家自然科学基金资助项目(81370283);国家自然科学基金青年科学基金项目(81100130)

摘　　要：目的探讨血清簇集蛋白水平与冠心病的关系。方法选取2017年2月—2018年4月在武汉大学人民医院行冠状动脉造影检查的患者139例,根据冠状动脉造影结果分为冠心病组81例和非冠心病组58例。比较两组患者一般资料和实验室检查指标,冠心病的影响因素分析采用二元Logistic回归分析。结果冠心病组患者男性比例、吸烟史阳性率、糖尿病病史阳性率高于非冠心病组(P<0.05);两组患者年龄、饮酒史阳性率、高血压病史阳性率、高脂血症发生率比较,差异无统计学意义(P>0.05)。冠心病组患者白细胞计数、血清簇集蛋白水平高于非冠心病组(P<0.05);两组患者血小板计数、尿酸及血清总胆固醇、三酰甘油、高密度脂蛋白、低密度脂蛋白、纤维蛋白原水平比较,差异无统计学意义(P>0.05)。二元Logistic回归分析结果显示,男性[OR=3.154,95%CI(1.285,7.736)]、糖尿病病史[OR=3.624,95%CI(1.296,10.136)]是冠心病的危险因素,而血清簇集蛋白水平[OR=0.924,95%CI(0.859,0.995)]是冠心病的保护因素(P<0.05)。结论冠心病患者血清簇集蛋白水平明显升高,是冠心病的保护因素。Objective To investigate the relationship between serum clusterin level and coronary heart disease(CHD).Methods A total of 139 patients undergoing coronary angiography examination were selected in the People's Hospital of Wuhan University from February 2017 to April 2018,and they were divided into CHD group(n=81)and non-CHD group(n=58)according to the coronary angiography examination results.General information and laboratory examination results were compared between the two groups,and binary Logistic regression analysis was used to analyze the influencing factors of CHD.Results Male proportion,positive rates of smoking history and diabetes history in CHD group were statistically significantly higher than those in non-CHD group(P<0.05),while no statistically significant differences of age,positive rate of drinking history or hypertension history,or incidence of hyperlipidaemia was found between the two groups(P>0.05).WBC and serum clusterin level in CHD group were statistically significantly higher than those in non-CHD group(P<0.05),while no statistically significant differences of PLT,UA,serum level of TC,TG,HDL,LDL or FIB was found between the two groups(P>0.05).Binary Logistic regression analysis results showed that,male〔OR=3.154,95%CI(1.285,7.736)〕and diabetes history〔OR=3.624,95%CI(1.296,10.136)〕were risk factors of CHD,while serum clusterin level was the protective factor of CHD〔OR=0.924,95%CI(0.859,0.995)〕(P<0.05).Conclusion Serum clusterin level is significantly elevated in patients with CHD,is the protective factor of CHD.

关 键 词：冠心病 簇集蛋白 影响因素分析 

分 类 号：R541.4[医药卫生—心血管疾病]