不同肥胖亚型血清sCD163、TNF-α、CRP水平与内脏脂肪指数的相关性研究  

Study on correlation between serum sCD163,TNF-α and CRP levels with visceral fat index in different obese subtypes

作　　者：张培培[1] 王晓丽[2] 唐潇潇 孙侃[2] 常向云[2] ZHANG Peipei;WANG Xiaoli;TANG Xiaoxiao;SUN Kan;CHANG Xiangyun(Medical School of Shihezi University,Shihezi,Xinjiang 832000,China;Department of Endocrinology and Metabolism,First Affiliated Hospital of Medical College,Xinjiang Shihezi University,Shihezi,Xinjiang 832000,China;Department of Clinical Psychology,Xinjiang Autonomous Region People′s Hospital,Urumqi,Xinjiang 830000,China)

机构地区：[1]石河子大学医学院,新疆石河子832000 [2]石河子大学医学院第一附属医院内分泌代谢科,新疆石河子832000 [3]新疆自治区人民医院临床心理科,乌鲁木齐830000

出　　处：《重庆医学》2018年第26期3375-3378,共4页Chongqing medicine

基　　金：国家自然科学基金资助项目(81660149)

摘　　要：目的讨论不同肥胖亚型内脏脂肪指数(VAI)与血清sCD163、肿瘤坏死因子α(TNF-α)、C反应蛋白(CRP)水平的关系。方法获取研究对象一般资料等信息,检测空腹血糖(FPG)、餐后2小时血糖(PBG)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、糖化血红蛋白(HbA1c)、丙氨酸转氨酶(ALT)、非酒精性脂肪肝(NAFLD)、尿酸(UA)等指标。将研究对象分为:体质量正常代谢正常(MHNW)组、代谢正常性肥胖(MHO)组、体质量正常代谢异常(MONW)组、代谢异常性肥胖(MAO)组。用ELISA法测定血清sCD163、TNF-α及CRP的浓度。结果 MONW、MHO、MAO组VAI高于MHNW组(P<0.05)。MONW、MHO、MAO组血清sCD163、TNF-α、CRP水平均高于MHNW组(P<0.05)。血清sCD163与VAI、UA、NAFLD、DBP、PBG、ALT呈正相关(P<0.05);血清TNF-α与VAI、UA、NAFLD、DBP、FBG呈正相关(P<0.05);血清CRP与VAI、UA、NAFLD、DBP、PBG、ALT呈正相关(P<0.05)。结论 MONW、MHO、MAO 3组人群中VAI与血清sCD163、TNF-α、CRP水平密切相关。Objective To investigate the relationship between visceral fat index(VAI)with serum sCD163,TNF-αand CRP levels in different types of obesity.Methods The information such as general data were obtained from the study subjects.The indicators of fasting blood glucose(FBG),postprandial 2 h blood glucose(PBG),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),glycosylated hemoglobin(HbA1C),alanine aminotransferase(ALT),non-alcoholic fatty liver(NAFLD)and uric acid(UA)were detected.The study subjects were divided into body mass normal metabolism(MHNW)group,metabolic normal obesity(MHO)group,normal body mass metabolic abnormality(MONW)group,and metabolic abnormal obesity(MAO)group.The serum of sCD163,TNF-αand CRP concentrations were detected by ELISA.Results VAI in the MONW,MHO and MAO groups was higher than that in the MHNW group(P<0.05).The levels of serum sCD163,TNF-αand CRP in the MONW,MHO and MAO groups were higher than those in the MHNW group(P<0.05).Serum sCD163 was positively correlated with VAI,UA,NAFLD,DBP,PBG and ALT(P<0.05);serum TNF-αwas positively correlated with VAI,UA,NAFLD,DBP and FBG(P<0.05);serum CRP was positively correlated with VAI,UA,NAFLD,DBP,PBG and ALT(P<0.05).Conclusion VAI is closely related to serum sCD163,TNF-αand CRP in the MHO,MONW and MAO groups.

关 键 词：肥胖 内脏脂肪指数 跨膜单核巨噬细胞血红蛋白清道夫受体 肿瘤坏死因子Α C反应蛋白质 

分 类 号：R723.14[医药卫生—儿科]