rCBF_(max)值对胶质瘤术前分级的价值及与MVD表达间关系的初步研究  

The study on rCBF_(max) value for predicting glioma grading before operation and the relationship between the MVD expression

作　　者：吴静 汪文胜 颜刘清 陈楷哲 林翰波 成丽娜 贺鹏 梁倩雯 WU Jing;WANG Wen-sheng;YAN Liu-qing;CHEN Kai-zhe;LIN Han-bo;CHENG Li-na;HE Peng;LIANG Qian-wen(Department of Medical Imaging,Guangdong 999 Brain Hospital,Guangzhou 510510,China)

机构地区：[1]广东三九脑科医院影像中心,广州510510

出　　处：《磁共振成像》2018年第6期417-421,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：广东省医学科学技术研究基金(编号:A2016380)~~

摘　　要：目的探讨三维动脉自旋标记(three-dimensional arterial spin labeling,3D-ASL)灌注成像参数平均最大相对脑血流量(mean maximum relative cerebral blood flow,rCBF_(max))在预测胶质瘤术前分级中的价值及与肿瘤微血管密度(microvessel density,MVD)表达间的关系。材料与方法回顾性分析经组织病理学证实的50例胶质瘤(高级别20例,低级别30例)3D-ASL图像,应用热点法获得肿瘤实体部分的平均最大相对脑血流量。应用免疫组化S-P法对以上病例的组织学标本进行MVD表达的检测,结果进行统计学分析。结果 30例低级别胶质瘤的平均rCBF_(max)值、MVD值分别为1.69±1.27、25.43±13.03,20例高级别胶质瘤平均rCBF_(max)值、MVD值分别为3.18±1.46、58.69±20.39,两组间差异均有统计学意义(P<0.01),且与级别呈正相关(r=0.620、0.698,P<0.01),rCBF_(max)值与MVD值呈正相关(r=0.723,P<0.01)。结论 rCBF_(max)值有助于胶质瘤术前分级诊断且与肿瘤微血管密度呈正相关,可从一定程度上术前预测胶质瘤生物学行为。Objective:To explore the rCBFmax value for predicting glioma grading before operation and the relationship with MVD expression.Materials and Methods:3D-ASL images from 50 patients with pathologically proven gliomas(high grade:n=20,low grade:n=30)were analyzed retrospectively.The mean maximum relative cerebral blood flow was obtained by the hot spot method.The MVD of surgical specimen were measured.The results were analyzed statistically.Results:The mean rCBFmax,and MVD of low grade gliomas(n=30)were 1.69±1.27,25.43±13.03,while the high grade gliomas(n=20)were 3.18±1.46,58.69±20.39,the difference between the two groups was statistically significant(P<0.01)and was positively correlated with the grade(r=0.620,0.698,P<0.01).rCBFmax was positively correlated with MVD(r=0.723,P<0.01).Conclusions:The rCBFmax value is useful for predicting glioma grade before operation and is related to tumor microvessel density.The biologic behavior of glioma can be predicted to a certain extent.

关 键 词：胶质瘤 肿瘤分级 动脉自旋标记 磁共振成像 微血管密度 

分 类 号：R445.2[医药卫生—影像医学与核医学] R739.41[医药卫生—诊断学]