精神分裂症海马前后亚区结构改变的磁共振成像研究  

Magnetic resonance imaging study on the structural changes of anterior and posterior hippocampal subfields in schizophrenia patients

作　　者：郭攀飞 李欣蔚 李淑宇[1,2] GUO Pan-fei;LI Xin-wei;LI Shu-yu(School of Biological Science&Medical Engineering,Beihang University,Beijing 100083,China;Beijing Advanced Innovation Center for Biomedical Engineering,Beihang University,Beijing 100083,China)

机构地区：[1]北京航空航天大学生物与医学工程学院,北京100083 [2]北京航空航天大学生物医学工程高精尖创新中心,北京100083

出　　处：《磁共振成像》2018年第6期433-438,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金项目(编号:81471731)~~

摘　　要：目的通过人脑结构磁共振成像探讨精神分裂症患者前、后海马结构的改变,以及认知障碍病理生理机制。材料与方法选取符合纳入标准的精神分裂症患者72例和健康人群74名。比较海马、前海马和后海马体积的组间差异(将年龄和性别作为协变量),进一步将存在差异的脑区的体积值与认知得分进行相关分析。结果 (1)患病组两侧海马、前海马、后海马体积均显著小于对照组(P<0.05);(2)患病组后海马体积与言语学习能力正相关,右侧前海马体积与推理/问题解决能力正相关。结论精神分裂症患者前后海马体积萎缩模式为理解精神分裂症患者认知障碍病理生理机制提供新的依据。Objective:This study aims at investigating the changes of anterior and posterior hippocampal formation in patients with schizophrenia using structural magnetic resonance imaging(MRI)technique,and exploring the pathophysiological mechanism of cognitive disorders.Materials and Methods:A total of 72 schizophrenia patients and 74 healthy controls were included in our present study.We compared the volume differences in the whole hippocampus,anterior hippocampus,and posterior hippocampus between patients and controls,using age and sex as covariates,and further analyzed the correlations among clinical cognitive scores and the volumes which were significantly different between two groups.Results:(1)The volumes of hippocampus,anterior hippocampus and posterior hippocampus on both sides(left and right)of the patients group were significantly smaller than those of the control group(P<0.05).(2)In patient group,the posterior hippocampal volume was positively correlated with verbal learning ability,and the anterior hippocampal volume on the right side was positively correlated with reasoning/problem solving ability.Conclusions:The atrophy patterns of anterior and posterior hippocampus we found in this study,provided new evidences for understanding the pathophysiology of cognitive impairment in schizophrenia patients.

关 键 词：精神分裂症 磁共振成像 海马 认知障碍 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.3[医药卫生—诊断学]