199例老年乳腺癌患者治疗的回顾性研究  

Retrospective Study of the Treatment of 199 Elderly Breast Cancer Patients

作　　者：张小丽[1] 海涛[1] 李非[1] ZHANG Xiaoli;HAI Tao;LI Fei(Department of General Surgery,Xuanwu Hospital,Capital Medical University,Beijing 100053,China)

机构地区：[1]首都医科大学宣武医院普外科,北京100053

出　　处：《中国继续医学教育》2018年第27期77-79,共3页China Continuing Medical Education

摘　　要：目的回顾性分析我院老年乳腺癌患者治疗及生存状况。方法选择2012年1月—2016年12月年龄大于65岁的老年乳腺癌患者199例。收集患者临床资料进行分析。结果 199例患者中91.48%合并系统性疾病。85.43%为浸润性导管癌。Luminal型占81.82%。Ⅰ期和Ⅱ期患者占73.15%。86.43%的患者接受手术治疗,保乳手术比例39.86%。随访完成121例患者,102例患者无进展生存,17例复发,2例死亡。无进展生存患者中早期患者比例、Luminal分型、根治性手术患者人数均高于复发死亡组(P<0.05)。在102例无病生存的患者中,内分泌治疗依存性高达89.33%。而在死亡复发组无患者进行内分泌治疗及其他术后辅助治疗。结论肿瘤分期和分子分型是决定老年乳腺癌患者预后的重要因素。根治性手术对于提高可切除早期乳腺癌患者无进展生存意义重大。内分泌治疗是老年乳腺癌患者主要的术后辅助治疗手段。Objective To review the treatment and survival of the elderly breast cancer patients in our hospital.Methods 199 cases of breast cancer aged more than 65 years old from January 2012 to December 2016 were collected.The clinical data of the patients was analyzed.Results 91.48%of the elderly patients were associated with systemic diseases.85.43%was invasive ductal carcinoma.Type Luminal accounted for 81.82%.Stage I and stage II patients accounted for 73.15%.86.43%of the patients received surgical treatment,the proportion of breast conserving surgery was 39.86%.Final follow-up completed 121 patients,102 patients had progression free survival,17 relapsed and 2 died.The proportion of early stage patients,Luminal classification and the number of patients undergoing radical surgery in patients with progression-free survival were significantly higher than those in patients with recurrent death(P<0.05).In 102 patients without disease,endocrine therapy had a high dependency of 89.33%.No patients in the death recurrence group received endocrine therapy and other postoperative adjuvant therapy.Conclusion Tumor staging and molecular typing are important factors determining the prognosis of elderly patients with breast cancer.Radical surgery is of great significance for improving progression free survival in patients with resectable early breast cancer.Endocrine therapy is the main postoperative adjuvant therapy for elderly patients with breast cancer.

关 键 词：老年乳腺癌 手术 前哨淋巴结活检 化疗 放疗 内分泌治疗 

分 类 号：R737[医药卫生—肿瘤]