依那普利和叶酸联合治疗H型高血压对血管内皮功能的影响  

Effect of Enalapril and Folic Acid on Vascular Endothelial Function in H-type Hypertension

作　　者：陈剑生 石其云 CHEN Jiansheng;SHI Qiyun(Internal Medicine Department,Wuhan Changdong Hospital,Wuhan Hubei 430074,China)

机构地区：[1]湖北省武汉长动医院内科,湖北武汉430074

出　　处：《中国继续医学教育》2018年第27期124-125,共2页China Continuing Medical Education

摘　　要：目的探讨依那普利联用叶酸治疗H型高血压的临床效果,并分析其对患者血管内皮功能的影响。方法选择我院2014年3月—2016年8月所收治的64例H型高血压患者作为本次研究病例对象,按照计算机表法将其分为研究组和对照组,每组32例,对照组行依那普利治疗,研究组在此基础上加用叶酸治疗,对比分析两组治疗后的NO、ET-1、sICAM-1、Hcy、IMT、SBPV与DBPV。结果研究组治疗后24小时SBPV与DBPV显著低于对照组,且研究组NO、ET-1、Hcy等临床指标均优于对照组,组间比较差异有统计学意义(P<0.05)。结论依那普利与叶酸联合治疗H型高血压的效果显著,能够有效改善患者的临床症状。Objective To investigate the clinical efficacy of enalapril combined with folic acid in the treatment of H-type hypertension and to analyze its effect on the vascular endothelial function in patients.Methods 64 cases of H-type hypertensive patients admitted to our hospital from March 2014 to August 2016 were selected as the study case.The patients were divided into study group and control group according to the computer table method,with 32 cases in each group.The control group was treated with enalapril,and the study group was treated with folic acid on the basis of it.The NO,ET-1,sICAM-1,Hcy,IMT,SBPV and DBPV of the two groups were compared and analyzed.Results The SBPV and DBPV were significantly lower in the study group than in the control group at 24 hours after treatment.The clinical parameters such as NO,ET-1,and Hcy were better in the study group than in the control group.There was a statistically significant difference between the groups(P<0.05).Conclusion The combination of enalapril and folic acid can significantly improve the clinical symptoms of H-type hypertension.

关 键 词：依那普利 叶酸 H型高血压 一氧化氮 血管内皮素 血浆可溶性细胞间粘附分子1 

分 类 号：R544[医药卫生—心血管疾病]