联合灌注加权和弥散加权成像鉴别毛细胞型星形细胞瘤与高级别星形细胞瘤  

Differentiation of Pilocytic Astrocytomas from High-grade Astrocytoma Using Magnetic Resonance Perfusion-weighted Imaging and Diffusion-weighted Imaging

作　　者：李玉萍[1] 陈群林[1] 曹代荣[1] 佘德君[1] 杨谢锋 郑颖彦 LI Yuping;CHEN Qunlin;CAO Dairong;SHE Dejun;YANG Xiefeng;ZHENG Yingyan(Department of Radiology,The First Affiliated Hospital of Fujian Medical University,Fuzhou 350005,China)

机构地区：[1]福建医科大学附属第一医院影像科,福州350005

出　　处：《福建医科大学学报》2018年第3期200-203,共4页Journal of Fujian Medical University

摘　　要：目的探讨PWI和DWI在毛细胞型星形细胞瘤(PA)与高级别星形细胞瘤(HGA)鉴别诊断中的应用价值。方法回顾性分析经手术病理证实的22例PA与41例HGA患者的常规MR、PWI及DWI资料。计算PA和HGA的相对脑血容量值(rCBV)及相对表观弥散系数值(rADC)。采用独立样本t检验及ROC曲线对数据进行分析。结果 PA的rCBV值(1.82±1.05)明显低于HGA(5.07±1.49),PA的rADC值(1.98±0.60)明显高于HGA(0.99±0.29),差别均有统计学意义(P<0.01)。当以rCBV值>3.02或rADC值≤1.24作为诊断HGA的阈值时,rCBV与rADC值具有较高的诊断准确率。2条ROC曲线下的面积AUCrCBV和AUCrADC分别为0.97及0.92,二者差别无统计学意义(P>0.05)。结论PWI和DWI对PA和HGA的鉴别诊断具有重要价值。Objective To evaluate the usefulness of perfusion-weighted imaging and diffusion-weighted imaging in the differentiation of pilocytic astrocytomas(PA)from high-grade astrocytomas(HGA). Methods Conventional MR imaging,PWI,and DWI were performed on 22 patients with PA and 41 patients with HGA. All lesions were confirmed by histopathology and the images were retrospectively reviewed. Relative cerebral blood volumes values were calculated from perfusion-weighted imaging and relative apparent diffusion coefficient values were calculated form diffusion-weighted imaging in each tumor. Independent t test and receiver operating characteristic(ROC)curve were used for statistical analysis. Results The rCBV values in PA were significantly lower than that in HGA[(1.82±1.05)vs(5.07±1.49),P<0.01). The rADC values in PA were significantly higher than that in HGA[(1.98±0.60)vs(0.99±0.29),P<0.01]. With the ROC curve analysis,if the rCBV 3.02 or rADC 1.24 was taken as a threshold to predict HGA,the high accuracy of rCBV and rADC could be reached. Conclusion Perfusion-weighted imaging and diffusion-weighted imaging are helpful in discriminating pilocytic astrocytomas from high-grade astrocytoma.

关 键 词：磁共振波谱学 毛细胞 听觉 星形细胞瘤 磁共振成像 

分 类 号：R322.81[医药卫生—人体解剖和组织胚胎学] R445.2[医药卫生—基础医学]