心血管疾病患者使用抗抑郁焦虑药物效益与风险评估  

Efficacy and Risk Assessment of Antidepressant and Anti-anxiety Drugs in Patients with Cardiovascular Disease

作　　者：龚山 王龙飞 余国龙[1] GONG Shan;WANG Longfei;YU Guolong(Department of Cardiology,Xiangya Hospital,Central South University,Changsha 410008,China)

机构地区：[1]中南大学湘雅医院心内科,长沙410008

出　　处：《医药导报》2018年第10期1194-1198,共5页Herald of Medicine

基　　金：湖南省财政厅社科基金项目(湘财社指[2017]61号)

摘　　要：心血管疾病(CVD)患者并发抑郁和(或)焦虑发生率高,抑郁和(或)焦虑增加CVD患者心血管不良事件、全因死亡及心血管病死亡的风险,因此,对CVD与抑郁和(或)焦虑共病患者进行药物治疗有必要性。不同类型的抗抑郁焦虑药物在不同的CVD患者中使用的安全性和有效性存在很大差异。该文基于抗抑郁焦虑药物在高血压、冠心病、心律失常、慢性心力衰竭等不同CVD患者的近期研究,重点关注当前常用的新型药物在CVD患者中应用的效益与风险,就临床常用抗抑郁焦虑药物疗效、不良反应及药物相互作用概况作一综述,目的是有助于临床医生对CVD与抑郁和(或)焦虑共病患者,正确选择抗抑郁和(或)焦虑药物治疗。Incidence rate of depression and/or anxiety is high in patients with cardiovascular disease(CVD).Depression and anxiety increased risks of adverse cardiovascular events including all-cause mortality and cardiovascular disease mortality in patients with CVD.There were significant differences in the safety and effectiveness in different types of antidepressant drugs used in different types of CVD patients.This paper,based on recent clinical researches about antidepressant and anxiolytic drugs in patients with hypertension,coronary heart disease,arrhythmia,chronic heart failure,focus on the benefits and risks of the new antidepressant and anxiolytic drugs commonly used in patients with CVD,and reviews the clinical curative effect,drug adverse reactions and interaction of commonly used antidepressant and anxiolytic drugs.The purpose is to help clinicians correctly choose antidepressant and anxiolytic drugs for patients with CVD combined with depression and/or anxiety.

关 键 词：抗抑郁焦虑药物 心血管疾病 效益 风险评估 

分 类 号：R971.43[医药卫生—药品]