腹腔镜子宫肌瘤剔除术后应用促性腺激素释放激素激动药预防子宫多发肌瘤复发  

Preventive Recurrence of GnRH-a on Multiple Hysteromyoma After Laparoscopic Myomectomy

作　　者：周琴[1] 杨润峰[2] 李莎 栗妍 ZHOU Qin;YANG Runfeng;LI Sha;LI Yan(Department of Obstetrics and Gynecology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Department of Obstetrics and Gynecology,Hubei Cancer Hospital,Wuhan 430079,China;Department of Obstetrics and Gynecology,the Central Hospital of Wuhan City,Wuhan 430010,China)

机构地区：[1]华中科技大学同济医学院附属同济医院妇产科,武汉430030 [2]湖北省肿瘤医院妇产科,武汉430079 [3]武汉市中心医院妇产科,武汉430010

出　　处：《医药导报》2018年第10期1217-1219,共3页Herald of Medicine

基　　金：国家自然科学基金资助项目(81402161)

摘　　要：目的分析腹腔镜下多发子宫肌瘤剔除术后应用促性腺激素释放激素激动药(GnRH-a)预防子宫多发肌瘤复发的效果。方法选取行腹腔镜子宫多发肌瘤剔除术患者148例,分为治疗组69例和对照组79例。两组均行腹腔镜下多发子宫肌瘤剔除术。治疗组术后皮下注射醋酸戈舍瑞林或曲谱瑞林或亮丙瑞林3.75 mg,间隔28 d,3~6次。随访2年观察其复发情况。比较两组术后复发情况。结果治疗组子宫体积在术后12,18,24个月均小于对照组(P<0.05或P<0.01)。治疗组术后18,24个月复发率低于对照组(P<0.05)。结论多发子宫肌瘤剔除术后用GnRH-a治疗对抑制子宫多发肌瘤复发有确切效果。Objective To investigate preventive recurrence effect of GnRH-a on multiple hysteromyoma after laparoscopic myomectomy.Methods A total of 148 patients of multiple hysteromyoma were randomly divided into control group(n=79)and treatment group(n=69).Patients were given laparoscopic myomectomy,and patients in the treatment group were given 3.75 mg of goserelin acetate,triptorelin or leuprorelin for 3 to 6 times with an 28 d interval.Therapeutic effect was followed for 2 years and recurrence rate was compared between two groups.Results The uterine volume was significantly smaller in treatment group than control group(P<0.05)at 12th,18th and 24 th month after laparoscopic myomectomy(P<0.05).Recurrence rate was significantly lower in treatment group than control group at 18th and 24th months after laparoscopic myomectomy(P<0.05).Conclusion GnRH-a treatment is effective for reducing recurrence rate in multiple hysteromyoma patients after laparoscopic myomectomy.

关 键 词：促性腺激素释放激素激动药 子宫多发肌瘤 腹腔镜子宫肌瘤剔除术 

分 类 号：R977.12[医药卫生—药品] R713.4[医药卫生—药学]