血必净注射液治疗急性百草枯中毒临床疗效的Meta分析  

Efficacy of Xuebijing Injection in Treatment of Acute Paraquat Poisoning:A Meta-analysis

作　　者：柳舟[1] 董卫国[2] 余追[1] 张亮[3] 姚兰[1] 左小淑 侯果[1] 刘亚男 LIU Zhou;DONG Weiguo;YU Zhui;ZHANG Liang;YAO Lan;ZUO Xiaoshu;HOU Guo;LIU Yanan(Department of Intensive Care Unit,Renmin Hospital of Wuhan University,Wuhan 430060,China;Department of Grastroenterology,Renmin Hospital of Wuhan University,Wuhan 430060,China;Department of Radiology,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院重症医学科,武汉430060 [2]武汉大学人民医院消化内科,武汉430060 [3]武汉大学人民医院放射科,武汉430060

出　　处：《医药导报》2018年第10期1267-1275,共9页Herald of Medicine

基　　金：湖北省自然科学基金(WJ2017M016)

摘　　要：目的探讨血必净注射液治疗急性百草枯中毒(APQ)的临床疗效。方法计算机检索Pub Med、The Cochrane Library、EMbase、CNKI、CBM及万方数据库,查找血必净治疗急性百草枯中毒的随机对照试验(RCT),检索时限为建库至2017年10月15日,按照纳入及排除标准独立筛选文献、提取资料并用Rev Man5.3软件行Meta分析。结果纳入22个RCT,共计患者1240例。Meta分析结果显示:血必净组较对照组丙氨酸氨基转移酶低[MD=-115.53,95%CI(-182.50,-48.56)]、肌酐低[MD=-180.31,95%CI(-240.48,-120.14)]、白细胞计数低[MD=-6.89,95%CI(-9.54,-4.24)]及C反应蛋白低[MD=-7.65,95%CI(-8.75,-6.55)];氧饱和度高[MD=17.65,95%CI(13.45,21.85)]及近远期总体生存率高[RR=1.42,95%CI(1.30,1.55)];但两组在氧分压、二氧化碳分压及多器官功能衰竭发生率上差异无统计学意义。结论血必净注射液可较好改善急性百草枯中毒患者肝肾功能、减轻炎症反应、提高氧合水平及近远期生存率。Objective To systematically evaluate the efficacy of Xuebijing injection in treating acute paraquat poisoning(APQ).Methods The randomized controlled trials(RCTs)about Xuebijing injection for treatment of APQ was searched in PubMed,The Cochrane Library,EMbase,CNKI,CBM and WanFang Database from the date of their establishment to Oct 15th,2017.Two researchers independently screened the literature according to the inclusion and exclusion criteria,and extracted the data.Then,Meta-analysis was performed using RevMan 5.3 software.Results A total of 20 RCTs(1240 patients)were included.The results of meta-analysis showed that compared with control groups,Xuebijing groups had lower ALT[MD=-115.53,95%CI:-182.50,-48.56],lower Crea[MD=-180.31,95%CI(-240.48,-120.14)],lower WBC[MD=-6.89,95%CI(-9.54,-4.24)],lower CRP[MD=-7.65,95%CI(-8.75,-6.55)],and higher SpO 2[MD=17.65,95%CI(13.45,21.85)],meanwhile recent and long-term survival rate was much higher[RR=1.42,95%CI(1.30,1.55)].However,there were no significant statistical differences in PaO 2,PaCO 2 and the incidence of multiple organ dysfunction syndrome(MODS).Conclusion Xuebijing injection can protect APQ patients kidney and liver function,reduce inflammatory response,improve oxygenation level as well as recent and long-term survival rate.

关 键 词：血必净注射液 百草枯中毒 META分析 

分 类 号：R282[医药卫生—中药学] R595.3[医药卫生—中医学]