基于小鼠超微弱发光的中药药性研究初探  

The properties of traditional Chinese medicine research based on ultra-weak luminescence of mice

作　　者：周宝宸 杨美娜[2] 庞靖祥[2] 张玉风[1,2] 韩金祥[2] ZHOU Baochen;YANG Meina;PANG Jingxiang;ZHANG Yufeng;HAN Jinxiang(School of Medicine and Life Sciences,University of Jinan-Shandong Academy of Medical Sciences,Jinan 250020,China;Shandong Academy of Medical Sciences,Shandong Medical Biotechnological Center,Jinan 250062)

机构地区：[1]济南大学山东省医学科学院医学与生命科学学院,山东济南250020 [2]山东省医学科学院医药生物技术研究中心,山东济南250062

出　　处：《生物医学工程研究》2018年第3期371-376,共6页Journal Of Biomedical Engineering Research

基　　金：国家国际科技合作专项资助项目(2014DFA30380);山东省医学科学院医药卫生科技创新工程

摘　　要：利用生物超微弱发光检测仪,对经典热性药当归与经典寒性药黄芩中药煎煮液灌胃小鼠体表生物超微弱发光连续16 d检测,结果显示:(1)在基于小鼠超微弱发光的中药药性研究实验中灌胃小鼠的最佳检测时间范围为第5 d至第10 d;(2)当归组与空白组、黄芩组与空白组腹部与背部自发发光强度的比值之间存在显著性差异,提示灌胃小鼠的腹背自发发光强度的比值可作为表征中药寒热药性的指标。本研究结果可以为中药药性的研究提供新的思路。The angelica sinensis(hot)and radix scutellariae(cold)of traditional Chinese medicine decoction liquid lavage mice bioluminescent behavior were tested 16 d continuously by use of bioluminescent detector.The results showed that the best detection time of gavage mice in traditional Chinese medicine medicinal properties based on ultra-weak luminescence of mice was 5 d^10 d.There was a significant difference between the Chinese angelica group and the blank group,radix scutellariae and blank group spontaneous luminous,It showed that that ratio of spontaneous luminous intensity of gavage mice could characterize the cold and hot property of traditional Chinese medicine.The results can provide new idea for the traditional Chinese medicine medicinal properties.

关 键 词：小鼠 当归 黄芩 中药药性 生物光子 自发发光 栅藻 腹背比值 

分 类 号：R318[医药卫生—生物医学工程]